Vitamin K enhances the production of brain sulfatides during remyelination

PloS One
Daniela C PopescuErnest J Freeman

Abstract

Multiple sclerosis (MS) is a devastating neurological disease, which is characterized by multifocal demyelinating lesions in the central nervous system. The most abundant myelin lipids are galactosylceramides and their sulfated form, sulfatides, which together account for about 27% of the total dry weight of myelin. In this study we investigated the role of vitamin K in remyelination, by using an animal model for MS, the cuprizone model. Demyelination was induced in C57Bl6/J mice, by feeding them a special diet containing 0.3% cuprizone (w/w) for 6 weeks. After 6 weeks, cuprizone was removed from the diet and mice were allowed to remyelinate for either 1 or 3 weeks, in the absence or presence of vitamin K (i.p. phylloquinone, 2mg, three times per week). Vitamin K enhanced the production of total brain sulfatides, after both 1 week and 3 weeks of remyelination (n = 5, P-values were <0.0001), when compared with the control group. To determine whether or not there is a synergistic effect between vitamins K and D for the production of brain sulfatides, we employed a similar experiment as above. Vitamin K also increased the production of individual brain sulfatides, including d18:1/18:0, d18:1/20:0, d18:1/24:0, and d18:1/24:1 after ...Continue Reading

References

Jan 23, 1999·Journal of Neuroimmunology·M M HiremathG K Matsushima
May 10, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A HaffaN Binkley
Aug 20, 2003·Archives of Neurology·Frederik BarkhofPaul van der Valk
May 5, 2005·Nutrition Reviews·Natalia A Denisova, Sarah L Booth
Mar 3, 2006·The New England Journal of Medicine·Allan H Ropper
May 13, 2006·Journal of Neuropathology and Experimental Neurology·Samuel K Ludwin
Aug 24, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthias EckhardtVolkmar Gieselmann
Jun 18, 2008·Acta Neurologica Scandinavica. Supplementum·O TorkildsenL Bø
Sep 19, 2009·Acta Neuropathologica·Markus KippCordian Beyer
Jan 23, 2010·The Journal of Nutritional Biochemistry·Natalia A CrivelloSarah L Booth
Apr 21, 2012·Advances in Nutrition·Guylaine Ferland
May 24, 2012·Journal of Lipid Research·Tadanobu Takahashi, Takashi Suzuki
Nov 2, 2013·Nature Protocols·Vera MugoniMassimo M Santoro
Mar 25, 2014·Frontiers in Cellular Neuroscience·Viktoria GudiMartin Stangel
May 28, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Agnes E NystadOivind Torkildsen
Oct 8, 2014·ASN Neuro·Hilary H SachsWendy B Macklin
Dec 30, 2014·Biochimica Et Biophysica Acta·Sebastian SchmittMikael Simons
Feb 27, 2017·Biochimica Et Biophysica Acta. Biomembranes·J Martínez-GardeazabalR Rodríguez-Puertas

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Citations

Feb 13, 2020·Journal of Clinical Medicine·Davide MarangonMarta Fumagalli
Mar 12, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·John Michael S SanchezRobert S Fujinami
Mar 7, 2021·International Journal of Molecular Sciences·Luiza Ayumi Nishiyama MimuraAlexandrina Sartori
Jul 3, 2021·Nutrients·Alexander Popescu, Monica German
Jul 25, 2021·International Journal of Molecular Sciences·Marwa El SouryGiulia Ronchi
Jul 23, 2021·Neuronal Signaling·Eleanor Catherine Sams

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Methods Mentioned

BETA
protein assay

Software Mentioned

GraphPad Prism
GraphPad 7
ImageJ

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