Vitamin K requirement and warfarin tolerance in the hamster.

Proceedings of the Society for Experimental Biology and Medicine
D V Shah, J W Suttie

Abstract

A dietary deficiency of vitamin K has been demonstrated in the Syrian hamster. This species has also been shown to be relatively resistant to the action of the indirect anticoagulant Warfarin, and very sensitive to the anticoagulant action of the vitamin K antagonist chloro-K. These observations, and the hamster's apparently high requirement for the vitamin, indicate that it responds to vitamin K and vitamin K antagonists in the same fashion as Warfarin-resistant strains of rats.

Citations

Jun 1, 1980·Food and Cosmetics Toxicology·O TakahashiK Hiraga
Jul 22, 2006·Nutrition & Metabolism·Alison TovarSarah L Booth
Oct 1, 1984·The Journal of Hygiene·A A Bradfield, J E Gill
Jan 1, 1987·Reviews on Drug Metabolism and Drug Interactions·F A SutcliffeG G Gibson

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