Vitamin K2 promotes bone healing in a rat femoral osteotomy model with or without glucocorticoid treatment

Calcified Tissue International
Jun IwamotoJames K Yeh

Abstract

The purpose of the present preclinical study was to determine whether vitamin K(2) would promote bone healing in a rat femoral osteotomy model with or without glucocorticoid (GC) treatment. Thirty-eight 6 week-old female Sprague-Dawley rats underwent a unilateral osteotomy of the femoral diaphysis followed by intramedullary wire fixation and then were randomized into four groups that received the following treatment schedules: vehicle, vitamin K(2), GC + vehicle, and GC + vitamin K(2). GC (prednisolone, 2.5 mg/kg) was administered subcutaneously twice a week. Vitamin K(2) (menatetrenone, 30 mg/kg) was administered orally five times a week. After 8 weeks of treatment, the wires were removed and a bone histomorphometric analysis was performed on the bone tissue inside the callus. Vitamin K(2) administration to GC-untreated rats decreased the osteoclast surface/bone surface (OcS/BS), osteoblast surface (ObS)/BS, eroded surface (ES)/BS, and bone formation rate (BFR)/BS and increased the lamellar area/bone area. Although GC treatment increased the ES/BS and decreased the ObS/BS, BFR/BS, and lamellar area/bone area, vitamin K(2) administration to GC-treated rats decreased the OcS/BS and prevented an increase in the ES/BS and a decrea...Continue Reading

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Citations

Nov 15, 2011·Calcified Tissue International·Jun IwamotoHideo Matsumoto
Jul 1, 2014·Journal of Nutritional Science and Vitaminology·Jun IwamotoHideo Matsumoto
Feb 26, 2015·Acta Cirúrgica Brasileira·Priscilla Flores SilvaLouize Caroline Marques Oliveira
May 13, 2015·Foot & Ankle Specialist·Andrew Bernhard, Jorge Matuk
Dec 3, 2016·International Journal of Molecular Medicine·Yue-Lei ZhangYou-Shui Gao
Nov 16, 2017·International Journal of Endocrinology·Adriana J van BallegooijenNicolas Verheyen
May 24, 2017·Journal of Physical Therapy Science·Meral Bayramoğlu, Nuray Ünlütürk

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