Vitamin K‑dependent proteins involved in bone and cardiovascular health (Review)

Molecular Medicine Reports
Lianpu WenShuzhuang Li

Abstract

In postmenopausal women and elderly men, bone density decreases with age and vascular calcification is aggravated. This condition is closely associated with vitamin K2 deficiency. A total of 17 different vitamin K‑dependent proteins have been identified to date. Vitamin K‑dependent proteins are located within the bone, heart and blood vessels. For instance, carboxylated osteocalcin is beneficial for bone and aids the deposition of calcium into the bone matrix. Carboxylated matrix Gla protein effectively protects blood vessels and may prevent calcification within the vascular wall. Furthermore, carboxylated Gla‑rich protein has been reported to act as an inhibitor in the calcification of the cardiovascular system, while growth arrest‑specific protein‑6 protects endothelial cells and vascular smooth muscle cells, resists apoptosis and inhibits the calcification of blood vessels by inhibiting the apoptosis of vascular smooth muscle cells. In addition, periostin may promote the differentiation, aggregation, adhesion and proliferation of osteoblasts. Periostin also occurs in the heart and may be associated with the reconstruction of heart function. These vitamin K‑dependent proteins may exert their functions following γ‑carboxylatio...Continue Reading

References

Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J LianG Stein
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S A KernerJ W Pike
Jan 1, 1988·Annual Review of Nutrition·P A Price
May 11, 1982·Biochemistry·P V Hauschka, S A Carr
Dec 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J R Cairns, P A Price
Dec 1, 1995·In Vitro Cellular & Developmental Biology. Animal·A R SeversonL A Fitzpatrick
Mar 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y Koshihara, K Hoshi
Apr 2, 1999·Science·M F PittengerD R Marshak
Jul 15, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K HoriuchiA Kudo
May 16, 2000·Circulation Research·L W StantonR T White
May 26, 2001·Zeitschrift für Kardiologie·L J SchurgersC Vermeer
Jun 9, 2001·Experimental Biology and Medicine·J J MinguellP Conget
Oct 3, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N MiyakeY Koshihara
Dec 18, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·C R DhoreM J Daemen
Feb 7, 2002·The Biochemical Journal·Oliver PolitzSergij Goerdt
May 4, 2002·Stroke; a Journal of Cerebral Circulation·Jennifer L HuntEmile R Mohler
Aug 30, 2002·Current Opinion in Genetics & Development·Ava E Brent, Clifford J Tabin
Apr 12, 2003·Osteoarthritis and Cartilage·T NakaseH Yoshikawa
Aug 20, 2003·The Journal of Biological Chemistry·Su-Li ChengDwight A Towler
Sep 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Terence M DohertyTripathi B Rajavashisth
Oct 28, 2003·The Journal of Biological Chemistry·Paul A PriceTruclinh N Than
Oct 31, 2003·Nature·Quyen Q HoangDaniel S C Yang
Mar 17, 2004·The Proceedings of the Nutrition Society·Susanne Bügel
May 8, 2004·American Heart Journal·Astrid Trion, Arnoud van der Laarse
Sep 24, 2004·Circulation·Naruto KatsuragiKeijiro Sugimura
Oct 30, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Volkhard LindnerCalvin P H Vary
Oct 30, 2004·The Journal of Nutrition·Johanna M GeleijnseJacqueline C M Witteman
Jul 9, 2005·Nature Biotechnology·Michael A Laflamme, Charles E Murry
Dec 2, 2005·Expert Opinion on Biological Therapy·Jakob ReiserVincent F La Russa
Dec 20, 2005·Journal of Thrombosis and Haemostasis : JTH·I HasanbasicM Blostein
Jan 18, 2006·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Judith LitvinKenneth Margulies
Mar 31, 2006·Arthritis and Rheumatism·Tuhina NeogiDavid T Felson
Jun 28, 2006·Archives of Internal Medicine·Sarah CockayneDavid J Torgerson

❮ Previous
Next ❯

Citations

Feb 23, 2020·European Heart Journal·Raffaele De CaterinaMaria Fusaro
May 6, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M Kyla SheaSarah L Booth
Nov 26, 2019·Reviews in Endocrine & Metabolic Disorders·Ebtesam Abdullah Al-Suhaimi, Meneerah Abdulrahman Al-Jafary
Feb 23, 2019·International Journal of Molecular Sciences·Maurice HalderLeon Schurgers
Apr 8, 2020·International Journal of Molecular Sciences·Yi-Chou HouKuo-Cheng Lu
Apr 8, 2020·Frontiers in Bioengineering and Biotechnology·Cathrine Arnason Bøe, Helge Holo
Jun 13, 2020·Frontiers in Pharmacology·Xiao LinAirong Qian
Nov 12, 2020·Curēus·Abeer O ElshaikhIvan Cancarevic
Mar 7, 2021·Nutrients·Zeyad KhalilHarbans Sharma
Apr 2, 2021·Frontiers in Genetics·Nicolas LeursMélanie Debiais-Thibaud

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Critical Reviews in Food Science and Nutrition
Julia Khéde Dourado VillaHércia Stampini Duarte Martino
Clinical Cases in Mineral and Bone Metabolism : the Official Journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases
Maria FusaroMaurizio Gallieni
© 2022 Meta ULC. All rights reserved