Vitamin supplementation on the risk of venous thrombosis: results from the MEGA case-control study

The American Journal of Clinical Nutrition
Biljana A VučkovićWillem M Lijfering

Abstract

Whether vitamin supplements decrease venous thrombosis risk is controversial. Previous reports did not all take confounding fully into account, either by randomization or by extensive adjustment. The aim of our study was to determine whether vitamin supplementation decreases the risk of venous thrombosis. A large case-control study included 2506 patients with venous thrombosis, 2506 partner controls, and 2684 random-digit dialing (RDD) controls. When patients were compared with RDD controls, unconditional logistic regression was used to calculate ORs with 95% CIs. When patients were compared with partner controls, conditional logistic regression was used, providing further adjustment for unmeasured confounding. Vitamin use yielded a 37% lower risk of venous thrombosis than no vitamin use (OR: 0.63; 95% CI: 0.57, 0.70) when comparing patients with RDD controls. Adjustment for several putative confounders did not change the estimate (OR: 0.68; 95% CI: 0.61, 0.77). The fully adjusted ORs for vitamin A, vitamin B-6, vitamin B-12, folic acid, vitamin C, vitamin D, vitamin E, and multivitamin use were in the same range. However, when patients were compared with partner controls, ORs attenuated to unity. Results were similar for provo...Continue Reading

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Citations

Jan 26, 2018·American Journal of Epidemiology·Monica Ospina-RomeroWillem M Lijfering
Jan 31, 2017·Journal of Thrombosis and Haemostasis : JTH·V M MorelliS C Cannegieter
Jul 24, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Wen-Xiu Wu, Dong-Rui He
Oct 3, 2020·Antioxidants·Melanie ZieglerKarlheinz Peter
Nov 18, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F IngstadF Frihagen
Jan 7, 2021·American Journal of Physiology. Endocrinology and Metabolism·Prateek LohiaShweta Kapur

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