VITATOPS, the VITAmins TO prevent stroke trial: rationale and design of a randomised trial of B-vitamin therapy in patients with recent transient ischaemic attack or stroke (NCT00097669) (ISRCTN74743444).

International Journal of Stroke : Official Journal of the International Stroke Society
G J HankeyS Song

Abstract

Epidemiological studies suggest that raised plasma concentrations of total homocysteine (tHcy) may be a common, causal and treatable risk factor for atherothromboembolic ischaemic stroke, dementia and depression. Although tHcy can be lowered effectively with small doses of folic acid, vitamin B(12) and vitamin B(6), it is not known whether lowering tHcy, by means of B vitamin therapy, can prevent stroke and other major atherothromboembolic vascular events. To determine whether the addition of B-vitamin supplements (folic acid 2 mg, B(6) 25 mg, B(12) 500 microg) to best medical and surgical management will reduce the combined incidence of stroke, myocardial infarction (MI) and vascular death in patients with recent stroke or transient ischaemic attack (TIA) of the brain or eye. A prospective, international, multicentre, randomised, double blind, placebo-controlled clinical trial. One hundred and four medical centres in 20 countries on five continents. Eight thousand (6600 recruited as of 5 January, 2006) patients with recent (<7 months) stroke (ischaemic or haemorrhagic) or TIA (brain or eye). Randomisation and data collection are performed by means of a central telephone service or secure internet site. One tablet daily of eith...Continue Reading

Associated Clinical Trials

References

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Oct 26, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN Homocysteine Studies Collaboration
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Citations

Nov 12, 2010·Journal of Inherited Metabolic Disease·Robert ClarkeSarah Lewington
Jan 8, 2011·Cerebrovascular Diseases·Amytis TowfighiBruce Ovbiagele
Sep 3, 2010·Journal of the Neurological Sciences·Amytis TowfighiBruce Ovbiagele
Mar 17, 2009·Journal of the Neurological Sciences·Rajinder K DhamijaJ Bhattacharjee
Dec 6, 2007·Surgical Neurology·James Grotta, John Marler
Oct 27, 2010·Annals of Neurology·Osvaldo P AlmeidaGraeme J Hankey
May 4, 2010·Neurological Research·Mehdi MoghaddasiHadi Razjouyan
Mar 22, 2014·Lancet Neurology·Robert G HartUNKNOWN Cryptogenic Stroke/ESUS International Working Group
Mar 4, 2014·Lancet Neurology·Steven M GreenbergDavid J Werring
Sep 22, 2010·International Journal of Stroke : Official Journal of the International Stroke Society·Lonneke M L de LauDiederik W J Dippel
Apr 5, 2012·Stroke; a Journal of Cerebral Circulation·Graeme J HankeyUNKNOWN VITAmins TO Prevent Stroke (VITATOPS) Trial Study Group
Feb 5, 2015·Stroke; a Journal of Cerebral Circulation·Baback ArshiAmytis Towfighi
Apr 18, 2009·Stroke; a Journal of Cerebral Circulation·Katherine KasimanChristopher P L-H Chen
Mar 7, 2012·Pharmacotherapy·Kathleen A PackardEstella M Davis
Aug 18, 2017·The Cochrane Database of Systematic Reviews·Arturo J Martí-CarvajalMark Dayer
Jun 25, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Athena EnderamiHadi Darvishi-Khezri
Nov 22, 2020·Neurochemistry International·Bharath Chelluboina, Raghu Vemuganti
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yulia ShulpekovaVladimir Ivashkin

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Software Mentioned

VITAmins
Oxford Handicap Scor
VITATOPS

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