PMID: 16644614Apr 29, 2006Paper

Vitiligo associated with pegylated interferon and ribavirin treatment of patients with chronic hepatitis C: a case report

Advances in Therapy
Krzysztof TomasiewiczGrazyna Semczuk

Abstract

The use of pegylated interferon (PEG-IFN) and ribavirin is considered standard therapy for patients with chronic hepatitis C. Many adverse effects of IFN appear to be of autoimmune origin. Vitiligo is a hypomelanotic disease, whose cause, despite many investigations, remains unknown, although some evidence points to an autoimmune pathogenesis. This report describes a case of vitiligo that occurred during the third month of treatment with PEG-IFN and ribavirin. The sustained virologic response was the result of a 52-week regimen; however, hypomelanotic cutaneous patches persisted. Autoimmune adverse effects of IFN therapy, which may include vitiligo, should be carefully monitored. The decision about whether to discontinue treatment should be discussed with the patient, who must be informed that the lesions may persist.

References

Jan 1, 1994·Dermatology : International Journal for Clinical and Investigative Dermatology·K U SchallreuterJ Berger
Jan 1, 1996·Dermatology : International Journal for Clinical and Investigative Dermatology·H SimsekH Telatar
Aug 13, 2002·Dermatologic Clinics·J Mark Jackson
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael W Fried
Mar 8, 2003·Pigment Cell Research·Katia OngenaeJean-Marie Naeyaert
Jul 2, 2003·Journal of the European Academy of Dermatology and Venereology : JEADV·F C Antony, R A Marsden
Sep 1, 2004·Clinical Therapeutics·S James Matthews, Christopher McCoy
Sep 15, 2004·Journal of Clinical Gastroenterology·Nihat AkbayirLevent Erdem
Dec 15, 2004·Journal of Clinical Gastroenterology·Kris V Kowdley

❮ Previous
Next ❯

Citations

Jul 14, 2010·International Journal of Dermatology·Issam HamadahAbdulmajeed Alajlan
Oct 7, 2015·Frontiers in Endocrinology·Sara Salehi HammerstadYaron Tomer
Jan 1, 2013·Qatar Medical Journal·Mohamed Allam, Hassan Riad
Jan 7, 2016·Anais Brasileiros De Dermatologia·Renato Roberto Liberato Rostey, Francisco José Dutra Souto
Jul 21, 2009·Journal of Veterinary Pharmacology and Therapeutics·A ChicoineP Dowling
Nov 26, 2010·Journal of Veterinary Pharmacology and Therapeutics·G A AlbarellosM F Landoni
Mar 9, 2013·The Journal of Clinical Endocrinology and Metabolism·Salvatore Maria CorselloFrancesco Torino
Sep 25, 2012·The American Journal of Dermatopathology·Mai P Hoang, Daniela Kroshinsky
May 21, 2013·International Journal of Environmental Research and Public Health·Shan LvXiao-Nong Zhou
Feb 24, 2009·Journal of the American Academy of Dermatology·Ginette A Hinds, Peter Heald

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.