Vitiligo-like leucoderma during photochemotherapy for mycosis fungoides

The British Journal of Dermatology
D MimouniE Hodak

Abstract

We describe four patients with mycosis fungoides (MF) in whom depigmentation, and also leucotrichia in one, occurred following the resolution of the eruption during phototherapy (psoralen plus ultraviolet A treatment in three patients, climatotherapy in one). In all cases, the depigmentation was localized to the area of the pre-existing MF lesions. There was no clinically obvious phototoxicity. Biopsy study including S100 staining in all cases, and electron microscopy in one case, demonstrated the total absence of melanocytes, with no evidence of MF. It is suggested that the phototherapy may have activated a cell-mediated immunity leading to destruction of the melanocytes. We recommend that vitiligo-like leucoderma be added to the list of untoward effects of phototherapy in MF.

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Citations

Jul 21, 2004·Clinics in Dermatology·Elizabeth Knobler
Feb 21, 2008·Dermatology : International Journal for Clinical and Investigative Dermatology·Hatice SanliOsman Ilhan
Jun 16, 2004·Journal of the European Academy of Dermatology and Venereology : JEADV·D V KazakovW Kempf
Dec 23, 2003·Dermatologic Therapy·Elma D Baron, Seth R Stevens
Mar 8, 2003·Pigment Cell Research·Katia OngenaeJean-Marie Naeyaert
Nov 26, 2005·The British Journal of Dermatology·A C KnolB Dreno
Apr 24, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·A SwobodaB Eberlein-König
Nov 1, 2007·The British Journal of Dermatology·J S WilliamsD Creamer
Feb 26, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·R FriedlandE Hodak
Jul 10, 2004·Journal of the American Academy of Dermatology·Emmilia HodakMichael David

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