Vitiligo treatment with vitamins, minerals and polyphenol supplementation.

Indian Journal of Dermatology
Akrem JalelMohamed Hédi Hamdaoui

Abstract

Mammalian pigmentation results from the synthesis and accumulation of photo protective epidermal melanin. Melanin was formed from the amino acid precursor L-tyrosine within specialized cells, the melanocytes. Oxidative stress has been suggested to be the initial pathogenetic event in melanocyte degeneration with H(2)O(2) accumulation in the epidermis of patients with active disease. Auto immunity has been also suggested as another hypothesis in the pathogenesis of depigmentation disorders. Topical corticosteroids and phototherapy as common treatment modalities have been prescribed in patients with vitiligo. However, they are often not effective and safe (epidermal atrophy). Therefore, research for alternative therapies continues. To evaluate the beneficial effects of a supplementation with antioxidant vitamins (A, C, E) and minerals (zinc, selenium) for vitiligo treatment. Forty experimental autoimmune vitiligo mice C57BL6, aged from 5 to 12 months showing visible signs of induced vitiligo, were sequentially randomized into five parallel groups (8 mice per group). Each group mice was allocated an identical pre coded cage. the first group (SZV) received the ED + 1,4 g zinc (Zn) + 0.04 g selenium (Se) + vitamins (A 118 UI, C 8,5 ...Continue Reading

References

Jun 30, 1992·Journal of Photochemistry and Photobiology. B, Biology·M Dalle Carbonare, M A Pathak
Feb 15, 1988·Biochemical and Biophysical Research Communications·J J Podczasy, R Wei
Apr 1, 1994·Pigment Cell Research·M PicardoF Ippolito
Mar 1, 1993·Pigment Cell Research·J P Ortonne, S K Bose
Jan 8, 1998·Archives of Dermatology·T B Fitzpatrick
May 19, 1998·Pigment Cell Research·S PassiC De Luca

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Citations

Jul 10, 2010·Current Opinion in Pediatrics·Nanette B Silverberg
Feb 13, 2014·The Journal of Dermatology·Qinghai ZengRong Xiao
Jul 3, 2016·Biochimica Et Biophysica Acta·Joydip DasM Olufemi Suraju
May 31, 2019·International Journal of Dermatology·Fandresena A SendrasoaFahafahantsoa Rapelanoro Rabenja
Jul 7, 2020·BioMed Research International·Ting DaiLiang Bo
Dec 23, 2020·Clinical and Experimental Dermatology·T SearleF R Ali
Dec 11, 2020·The Science of the Total Environment·Marta Wacewicz-MuczyńskaMaria H Borawska

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