PMID: 8969739Dec 1, 1996Paper

Vitreous hemorrhage as an ophthalmic complication of galactosemia

The Journal of Pediatrics
H L LevyE de Juan

Abstract

A major complication of galactosemia is cataracts. This is usually considered to be the sole ophthalmic feature of this disorder. However, we have encountered vitreous hemorrhage, a very rare ophthalmic finding, in five neonates with galactosemia and have found four probable additional cases in the literature. All of these infants had severe neonatal manifestations of galactosemia and were discovered to have vitreous hemorrhage by ophthalmologic examination initiated by the observation of clouding of the eye or on a routine basis. The infants lost most or all vision from the affected eye. Retinal abnormalities were present in the involved eyes of the five neonates of whom we have direct knowledge. Thus we believe that retinal hemorrhage is the most likely source of the vitreous hemorrhage and that the coagulopathy associated with neonatal disease in galactosemia leads to vitreous hemorrhage. Prompt recognition and therapy for the coagulopathy would likely prevent vitreous hemorrhage in galactosemia.

References

Oct 13, 1977·The New England Journal of Medicine·H L LevyJ O Klein
Jun 1, 1978·The Journal of Pediatrics·H L Levy, G Hammersen
Aug 1, 1976·American Journal of Ophthalmology·R A Wiznia, J Price
Mar 1, 1980·Obstetrics and Gynecology·S LevinV Insler
Sep 1, 1994·Archives of Ophthalmology·P J Ferrone, E de Juan
Dec 1, 1961·The Journal of Pediatrics·D Y HSIA, F A WALKER

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Citations

Jun 9, 2000·Eye·D Taylor
Jun 19, 1998·The New England Journal of Medicine·A C DuhaimeR A Zimmerman
Feb 6, 2002·Archives of Disease in Childhood·A M Kemp
Jan 1, 2011·BMJ Case Reports·Levinus A BokMichèl Willemsen
Feb 19, 2013·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Pukhraj RishiJay Chhablani
Mar 11, 2016·Neurologia Medico-chirurgica·Hiroshi KaribeTeiji Tominaga
May 3, 2006·Ophthalmology·Marc J SpirnG Baker Hubbard
Aug 10, 2005·Pediatric Neurology·Keith R RidelDonald L Gilbert
Oct 2, 2015·Journal of Ophthalmic & Vision Research·Aditya SudhalkarMudit Tyagi
Aug 24, 2006·Annals of Tropical Paediatrics·Emine ZenginVolkan Etuş
Feb 24, 2016·Clinics in Dermatology·Julio A Urrets-ZavalíaAndrzej Grzybowski
Jul 21, 2005·Acta Ophthalmologica Scandinavica·Hans C Fledelius
Dec 22, 1999·Journal of Inherited Metabolic Disease·M RuizM D Boleda
May 28, 2009·Deutsches Ärzteblatt International·Jakob MatschkeMarkus Glatzel
Dec 19, 2020·Current Opinion in Pediatrics·Natasha ShurTanya Hinds
Jun 25, 2005·Journal français d'ophtalmologie·E LaumonierJ F Rouland

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