Vitreous levels of interleukine-8 and monocyte chemoattractant protein-1 in macular oedema with branch retinal vein occlusion

Eye
A FonollosaV Martinez-Castillo

Abstract

To investigate whether interleukine-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) are related with macular oedema in patients with branch retinal vein occlusions (BRVOs). Retrospective case-control study. Nineteen patients who had macular oedema due to BRVO and nine patients with non-ischaemic ocular diseases (control group). Macular oedema was examined by optical coherence tomography. Both venous blood and vitreous samples were obtained at the time of vitreoretinal surgery. IL-8 and MCP-1 levels in vitreous fluid and plasma were determined with enzyme-linked immunosorbent assay kits. Variables were compared with the Mann-Whitney U-test, Wilcoxon's signed-ranked test, and the chi2-test, when appropriate. To examine correlations, Spearman's rank-order correlation coefficients were calculated. Statistical significance was set at P<0.05. The vitreous fluid levels of IL-8 (median: 63.5 pg/ml) and MCP-1 (median: 1522.4 pg/ml) were significantly higher in the patients with BRVO than in the control group (median: 5.1 and 746.5 pg/ml respectively; P<0.001 and <0.001 respectively). Vitreous IL-8 and MCP-1 were significantly correlated in patients with BRVO (P=0.009). Both IL-8 and MCP-1 were elevated in the vitreous fluid of p...Continue Reading

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Citations

Jun 12, 2013·Experimental Eye Research·Chuan SunYong Tao
Feb 11, 2015·Cell Biochemistry and Biophysics·Peipei Zhang, Zhanyu Zhou
Sep 27, 2013·International Journal of Molecular Medicine·Jiaqi YaoQinghuai Liu
Jul 29, 2019·Journal of Neuroinflammation·Christophe RoubeixFlorian Sennlaub
Apr 13, 2021·The Keio Journal of Medicine·Deokho LeeToshihide Kurihara
Jun 2, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hongfang YongLing Zuo

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