Vitreous penetration of levofloxacin in the uninflamed phakic human eye

The British Journal of Ophthalmology
E N HerbertC Groenewald

Abstract

To assess the vitreous penetration of oral levofloxacin (a new fluoroquinolone antibiotic with improved Gram positive activity) in uninflamed phakic eyes. 15 patients for macula hole surgery were recruited to the study. 10 received a single 500 mg dose of levofloxacin by mouth preoperatively. Five acted as controls. Serum and undiluted vitreous samples were obtained at surgery and analysed by HPLC. Levofloxacin was detectable 2.5 hours after administration in the vitreous. A peak concentration of 1.6 microg/ml (or mg/l) was measured between 2.5 and 4 hours post-dose. Oral levofloxacin reaches the vitreous rapidly in the uninflamed phakic eye. Levels did not reach MIC(90) for the commonest infecting organisms. Nevertheless, levofloxacin would be expected to be active against a higher proportion of infecting organisms than either ciprofloxacin or ofloxacin.

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Citations

Oct 28, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Zhaoxin JiangQianying Gao
Dec 14, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Yao-Lin LiuTzyy-Chang Ho
Dec 26, 2008·The Journal of Antimicrobial Chemotherapy·Juan P HorcajadaJosep Mensa
Feb 10, 2006·Retina·Patrick CostelloJ Andre Melendez
May 27, 2005·Antimicrobial Agents and Chemotherapy·Federico PeaMario Furlanut
Jan 26, 2012·International Journal of Nanomedicine·Zhaoxin JiangQianying Gao
Feb 16, 2013·Journal français d'ophtalmologie·P GoldschmidtC Chaumeil
Mar 15, 2011·Survey of Ophthalmology·Neelakshi BhagatMarco Zarbin
Feb 15, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C ChiquetA Carricajo
May 9, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Christine PeragineLesley Palmay
Oct 4, 2013·International Ophthalmology Clinics·Alice Lorch, Lucia Sobrin
Nov 21, 2007·Annals of Ophthalmology·Emile CalendaOlivier Genevois
May 28, 2021·Clinical Ophthalmology·Asad F DurraniDavid N Zacks
Nov 7, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Tapan P PatelVaidehi S Dedania

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