Vitreous Seeds in Retinoblastoma: Clinicopathologic Classification and Correlation

Ophthalmology
Alec L AmramPatricia Chévez-Barrios

Abstract

A recent classification scheme for retinoblastoma vitreous seeds has shown promise in predicting treatment response. For the first time, we correlate this clinical classification scheme with its histopathologic features. Retrospective review. Enucleated eyes received at the pathology department of the Retinoblastoma Center of Houston from 2010 to 2015. Macroscopic photographs of the enucleated eyes of patients with retinoblastoma were analyzed to select those with vitreous seeds. Cases with adequate material for clinicopathologic correlation were selected for further analysis, and clinical photographs were reviewed. Routine histopathologic slides were reviewed and compared with the clinical and macroscopic photographs. Seeds were classified as type 1 ("dust"), type 2 ("sphere"), or type 3 ("cloud"). To confirm the presence of macrophages, CD68 immunohistochemical staining was used. Synaptophysin was used to stain retinoblastoma cells. To correlate clinical vitreous seed type with histopathologic features. A total of 14 eyes with adequate amounts of tumor seeds along with clinical and macroscopic photographic correlation were selected from a total of 138 eyes reviewed. Type 1 seeds consisted of individual viable tumor cells and ...Continue Reading

Citations

Apr 24, 2018·Journal of Pediatric Hematology/oncology·Eun Hye JungYoung Suk Yu
Mar 26, 2019·International Ophthalmology Clinics·Jesse L BerryJonathan W Kim
Sep 8, 2018·Investigative Ophthalmology & Visual Science·Zachary K GoldsmithMatthew W Wilson
Jul 10, 2019·Journal of Pediatric Ophthalmology and Strabismus·Basil K WilliamsCarol L Shields
Mar 4, 2020·Cell Death Discovery·Arthur AubryRod Bremner
Mar 6, 2019·International Journal of Molecular Sciences·Ursula WinterPaula Schaiquevich
Feb 16, 2021·Clinics in Perinatology·Frank Y Lin, Murali M Chintagumpala
Jan 20, 2021·Cell Death Discovery·Arthur AubryRod Bremner
Jun 30, 2021·Clinical & Experimental Ophthalmology·Swathi Kaliki
Aug 4, 2021·The British Journal of Ophthalmology·Ankit Singh TomarUNKNOWN American Joint Committee on Cancer Ophthalmic Oncology Task

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