Vitronectin-dependent invasion of epithelial cells by Neisseria gonorrhoeae involves alpha(v) integrin receptors

FEBS Letters
M DehioThomas F Meyer

Abstract

Binding of vitronectin (VN) to Neisseria gonorrhoeae expressing the heparan sulfate proteoglycan (HSPG) specific Opa50 protein was recently shown to trigger bacterial internalization into distinct epithelial cell lines. We have investigated the role of VN-binding integrin receptors and protein kinase C (PKC) in VN-triggered bacterial uptake. Blocking integrin function by RGDS peptides or by antibodies specific to alpha(v)beta5 or alpha(v)beta3 resulted in an abrogation of VN-triggered bacterial internalization. Moreover, inhibitors of PKC were found to block VN-triggered uptake. The essential role of alpha(v) integrins and the presumable involvement of PKC in VN-triggered gonococcal uptake are discussed.

References

Mar 1, 1975·Clinical Obstetrics and Gynecology·H H Handsfield
Jan 1, 1991·Annual Review of Cell Biology·K T Preissner
Oct 23, 1987·Science·E Ruoslahti, M D Pierschbacher
Sep 1, 1983·Reviews of Infectious Diseases·Z A McGeeR G Horn
Dec 1, 1995·Science·M FriedlanderD A Cheresh
Aug 4, 1995·The Journal of Biological Chemistry·T S PanettiP J McKeown-Longo
Aug 1, 1995·The Journal of Experimental Medicine·T ChenJ Swanson
Oct 1, 1993·Current Opinion in Cell Biology·B Felding-Habermann, D A Cheresh
Jan 31, 1997·The Journal of Biological Chemistry·V Pijuan-Thompson, C L Gladson
Mar 1, 1997·Infection and Immunity·T D Duensing, J P van Putten
Mar 28, 1997·The Journal of Biological Chemistry·E S OhJ R Couchman
May 5, 1997·The Journal of Experimental Medicine·T ChenE C Gotschlich
Mar 1, 1995·Trends in Cell Biology·R R Isberg, G T Van Nhieu

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Citations

Aug 26, 1998·Folia Microbiologica·T F Meyer
Jun 4, 1998·Thrombosis Research·K T Preissner, D Seiffert
Nov 9, 2002·FEMS Immunology and Medical Microbiology·Thomas Eberhard, Måns Ullberg
Aug 3, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·D JohM Höök
Feb 26, 1999·Trends in Microbiology·C DehioT F Meyer
Mar 5, 2003·Current Opinion in Microbiology·Christof R Hauck, Thomas F Meyer
Feb 27, 1999·Current Opinion in Microbiology·M NaumannT F Meyer
May 25, 2002·Cellular Microbiology·Ozlem YilmazRichard J Lamont
Oct 19, 2004·Clinical Microbiology Reviews·Jennifer L Edwards, Michael A Apicella
Jun 23, 2006·Infection and Immunity·Christiane KühleweinThomas Rudel
Oct 16, 2002·Infection and Immunity·Leah E ColeChristopher Elkins
Oct 14, 2000·Annual Review of Cell and Developmental Biology·A J Merz, M So
Apr 2, 2004·Cellular Microbiology·Elsa I Castañeda-RoldánJorge A Girón
Apr 29, 2015·Molecular BioSystems·Marian MadarMangesh Bhide
Mar 15, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nir TsabarDale Frank
Sep 3, 2010·Molecular Microbiology·Birendra SinghKristian Riesbeck
Jul 12, 2005·The Journal of Biological Chemistry·Jeremy MooreJeremy P Derrick
Jan 24, 2002·The Journal of Biological Chemistry·Sunil K Sukumaran, Nemani V Prasadarao
Jul 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Teresia HallströmKristian Riesbeck
Jun 3, 2020·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Lacie M WernerAlison K Criss

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