Vive la différence: males vs females in flies vs worms

Annual Review of Genetics
T W Cline, B J Meyer

Abstract

For 600 million years, the two best-understood metazoan species, the nematode Caenorhabditis elegans and fruit fly Drosophila melanogaster, have developed independent strategies for solving a biological problem faced by essentially all metazoans: how to generate two sexes in the proper proportions. The genetic program for sexual dimorphism has been a major focus of research in these two organisms almost from the moment they were chosen for study, and it may now be the best-understood general aspect of their development. In this review, we compare and contrast the strategies used for sex determination (including dosage compensation) between "the fly" and "the worm" and the way this understanding has come about. Although no overlap has been found among the molecules used by flies and worms to achieve sex determination, striking similarities have been found in the genetic strategies used by these two species to differentiate their sexes.

References

Oct 1, 1979·Genetics·J E Madl, R K Herman
Mar 1, 1977·Developmental Biology·J E Sulston, H R Horvitz
Nov 11, 1992·Nucleic Acids Research·H SakamotoY Shimura
Aug 1, 1991·Journal of Biomechanical Engineering·W M LaiV C Mow
Nov 1, 1991·Genes & Development·L C Ryner, B S Baker
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·L M JohnsonM Grunstein

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Citations

Mar 21, 1998·Developmental Genetics·A M KeohaneB M Turner
Jun 10, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Fisher, M Caudy
Nov 21, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·I MarínB S Baker
Jan 1, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Patricia GrahamPaul Schedl
Mar 27, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D Bopp
Apr 21, 2011·Chromosoma·Per Stenberg, Jan Larsson
Jul 6, 2006·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Jan Larsson, Victoria H Meller
Nov 30, 2011·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·M ClintonD McBride
Aug 18, 2010·Genetica·Jayendra Nath ShuklaJavaregowda Nagaraju
Nov 15, 2003·Journal of Theoretical Biology·Thomas MacCarthyAndrew Pomiankowski
Apr 24, 1999·Molecular and Biochemical Parasitology·A P Underwood, A E Bianco
Sep 28, 2002·Trends in Genetics : TIG·Audrey E ChristiansenBruce S Baker
Apr 28, 1999·Trends in Genetics : TIG·P Silar, M J Daboussi
Apr 27, 2000·Trends in Ecology & Evolution·H Ellegren
Oct 12, 2000·Gene·L V Pereira, L R Vasques
May 10, 2000·Current Opinion in Cell Biology·A Franke, B S Baker
Feb 18, 1998·Current Opinion in Neurobiology·D B Kelley
Dec 23, 1999·Current Opinion in Neurobiology·S F Goodwin
Sep 13, 2002·Current Biology : CB·Amanda Swain
Feb 8, 2003·Current Biology : CB·Mariana F Wolfner
Feb 1, 2000·Trends in Cell Biology·V H Meller
Aug 28, 2003·Microbes and Infection·Uyen TramWilliam Sullivan
Jul 12, 2002·Nature·Tom Maniatis, Bosiljka Tasic
Jul 5, 2002·Nature·Diana J Starr, Thomas W Cline
Oct 31, 2006·Nature·UNKNOWN Honeybee Genome Sequencing Consortium
Nov 24, 2011·Nature Reviews. Molecular Cell Biology·Jeannie T Lee
Aug 24, 2004·Nature Reviews. Neuroscience·Arthur P Arnold
Dec 6, 2011·Nature Structural & Molecular Biology·Eda YildirimJeannie T Lee
May 10, 2002·Insect Molecular Biology·S Hinson, R N Nagoshi
Nov 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Alejandra N GonzálezJames W Erickson
Jan 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Gretchen KappesPaul Schedl
Nov 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Teiya KijimotoJusten Andrews

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Methods Mentioned

BETA
transgenic
two-hybrid
co-immunoprecipitation

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