VLDL compositional changes and plasma levels of triglycerides and high density lipoprotein

Clinica Chimica Acta; International Journal of Clinical Chemistry
Fernando BritesRegina Wikinski

Abstract

VLDL chemical composition is related to plasma levels of triglycerides and HDL-cholesterol. We evaluated patients with primary hypertriglyceridemia with or without hypoalphalipoproteinemia and subjects with normotriglyceridemia with hypoalphalipoproteinemia. The pattern observed in all the groups was an enrichment in the triglyceride content of VLDL and in apo B-VLDL. Compared to controls, LpC-III:B levels were higher in hypertriglyceridemic patients with low or normal HDL-cholesterol levels (7.3 +/- 0.6 vs. 14.9 +/- 1.8 and 12.3 +/- 2.8 mg/dl; P < 0.005 and P < 0.01, respectively) and LpE:B concentration was only increased in patients with hypertriglyceridemia and normal HDL-cholesterol levels (3.1 +/- 0.5 vs. 6.3 +/- 1.0 mg/dl; P < 0.01). The activity of the cholesteryl ester transfer protein was higher in hypertriglyceridemic patients with low HDL-cholesterol levels than in controls (380 +/- 25 vs. 262 +/- 14% cholesteryl esters/ml.h; P < 0.001). The most atypical VLDL particle was found in patients who combined an accumulation of VLDL particles and a reduction in HDL-cholesterol concentration. These two parameters represent both ends of the cholesteryl ester-triglyceride transfer, a crucial factor for VLDL chemical composit...Continue Reading

References

Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·B W ShenF J Kézdy
Apr 11, 1987·Lancet·R P DonahueK Yano
Jan 1, 1986·Methods in Enzymology·V N Schumaker, D L Puppione
Jan 1, 1986·Methods in Enzymology·J H Tollefson, J J Albers
Jun 27, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·G AssmannH Schriewer
Oct 1, 1994·Atherosclerosis·J R Patsch
Oct 15, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·E ManzatoG Crepaldi
Jan 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·B LamarcheC Bouchard
Jun 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·L LagrostP Gambert

❮ Previous
Next ❯

Citations

Jun 13, 2012·Journal of Natural Science, Biology, and Medicine·Emeka E NebohFrank O Ezeugwu
May 13, 2008·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·L Gómez RossoF Brites
May 29, 2007·Atherosclerosis·María Belén BenítezFernando Brites
Mar 22, 2005·Archives of Medical Research·Leandro ParzianelloJanice C Coelho
Apr 11, 2008·Clinical Science·Esther M M OoiGerald F Watts

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.