Abstract
Metabolic syndrome (MetS) represents a cluster of metabolic derangements. Dyslipidemia is an important factor in MetS and is related to atrial fibrillation (AF). We hypothesized that very low density lipoproteins (VLDL) in MetS (MetS-VLDL) may induce atrial dilatation and vulnerability to AF. VLDL was therefore separated from normal (normal-VLDL) and MetS individuals. Wild type C57BL/6 male mice were divided into control, normal-VLDL (nVLDL), and MetS-VLDL (msVLDL) groups. VLDL (15 µg/g) and equivalent volumes of saline were injected via tail vein three times a week for six consecutive weeks. Cardiac chamber size and function were measured by echocardiography. MetS-VLDL significantly caused left atrial dilation (control, n = 10, 1.64 ± 0.23 mm; nVLDL, n = 7, 1.84 ± 0.13 mm; msVLDL, n = 10, 2.18 ± 0.24 mm; p < 0.0001) at week 6, associated with decreased ejection fraction (control, n = 10, 62.5% ± 7.7%, vs. msVLDL, n = 10, 52.9% ± 9.6%; p < 0.05). Isoproterenol-challenge experiment resulted in AF in young msVLDL mice. Unprovoked AF occurred only in elderly msVLDL mice. Immunohistochemistry showed excess lipid accumulation and apoptosis in msVLDL mice atria. These findings suggest a pivotal role of VLDL in AF pathogenesis for Met...Continue Reading
References
Sep 14, 1989·Nature·U BeisiegelK K Stanley
May 9, 2001·Drugs & Aging·K G Pugh, J Y Wei
Jul 4, 2003·Current Opinion in Lipidology·Jean E Schaffer
Mar 30, 2004·Diabetes Care·Youlian LiaoW Timothy Garvey
May 27, 2004·Diabetes Care·Ronald M Krauss
Nov 26, 2005·Cardiovascular Research·Thomas Pulinilkunnil, Brian Rodrigues
Feb 8, 2006·Circulation·Akio KawakamiFrank M Sacks
Mar 21, 2006·Cardiovascular Research·Toru AsaiToyoaki Murohara
Aug 1, 2006·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Ibrahim R HannaJonathan J Langberg
Nov 1, 2008·Circulation Research·Akio KawakamiMasayuki Yoshida
Sep 21, 2010·The Journal of Clinical Investigation·Ni-Huiping SonIra J Goldberg
Feb 23, 2011·Journal of Molecular and Cellular Cardiology·José CastellanoVicenta Llorente-Cortés
Mar 15, 2011·International Journal of Molecular Medicine·Seong-Min KimKyung-Hyun Cho
May 3, 2011·The American Journal of Cardiology·Rikki M TannerPaul Muntner
Jun 15, 2011·The Journal of Clinical Investigation·Jeanna C PermanJan Borén
Aug 2, 2011·Cardiovascular Research·Tineke van de WeijerPatrick Schrauwen
Sep 15, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi WatanabeMakoto Kodama
Dec 2, 2011·Journal of Obesity·Fengxia GePaul D Berk
Jan 10, 2012·Circulation. Arrhythmia and Electrophysiology·Faye L LopezAlvaro Alonso
Jan 27, 2012·Diabetes Care·Chu-Huang ChenChao-Yuh Yang
Mar 29, 2012·Cardiovascular Research·Roi CalVicenta Llorente-Cortés
Sep 25, 2012·International Journal of Cardiology·Casper N BangKristian Wachtell
Nov 20, 2012·Current Opinion in Cardiology·Laurent FauchierDominique Babuty
Jan 4, 2013·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jan 22, 2013·The American Journal of Medicine·Chen-Ying HungTsu-Juey Wu
Mar 26, 2013·European Journal of Pharmacology·Xue ZhouYun-qing Chen
Apr 10, 2013·American Journal of Therapeutics·Giacomo VeroneseHenrik Toft Sørensen
Jun 22, 2013·Clinical Cardiology·Marijana TadicCesare Cuspidi
Nov 10, 2013·Clinical Biochemistry·Seong-Min KimKyung-Hyun Cho
Dec 19, 2013·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Kueiyu Joshua LinCynthia C Taub
Apr 26, 2014·Circulation Research·Jordi HeijmanDobromir Dobrev
Jun 7, 2014·Journal of Cardiovascular Electrophysiology·Sanghamitra MohantyAndrea Natale
Mar 15, 2015·Cardiovascular Research·Desiree AbdurrachimMiranda Nabben
Citations
Apr 20, 2018·Clinical Cardiology·Michael A RosenbergKenneth J Mukamal
Sep 25, 2017·Scientific Reports·Hsiang-Chun LeeWen-Ter Lai
Jun 23, 2019·Journal of Clinical Medicine·Yi-Lin ShiouHsiang-Chun Lee
Feb 6, 2020·International Journal of Molecular Sciences·Hsiang-Chun Lee, Yi-Hsiung Lin
Sep 24, 2020·Lipids in Health and Disease·Hsiang-Chun LeeYi-Hsiung Lin
Jul 9, 2020·International Journal of Molecular Sciences·Yi-Hsiung LinChung-Hwan Chen
Jan 24, 2021·Cardiovascular Research·Wern Yew DingGregory Y H Lip
Mar 18, 2021·Scientific Reports·Ying-Shao LinShiou-Lan Chen