VNS therapy in clinical practice in children with refractory epilepsy

Acta Neurologica Scandinavica
L NagarajanM Lee

Abstract

To study the efficacy, tolerability and safety of the vagus nerve stimulation (VNS) therapy in clinical practice, in 16 children and adolescents with refractory epilepsy. We assessed the efficacy of VNS therapy, retrospectively by comparing seizure frequency, duration and severity at the time of most recent follow up (av: 24.9 months) to that in the 4 weeks prior to VNS surgery. Changes in quality of life, sleep and behaviour at last review was compared with that prior to VNS. Adverse effects elicited by specific questioning, spontaneous reporting and clinical examination are described. Vagus nerve stimulation resulted in a >50% reduction in seizure frequency in 62.5% of children with 25% achieving a >90% reduction. Vagus nerve stimulation was well tolerated in all but one of our cohort, with no serious side-effects. Our results support its role as one of the options in intractable childhood epilepsy.

Associated Clinical Trials

References

Jan 1, 1990·Epilepsia·R TerryJ Zabara
Jan 1, 1990·Epilepsia·R Gourley
Jul 1, 1990·Epilepsia·P BrunquellB S Russman
Jul 1, 1993·Neurology·B M UthmanJ F Wernicke
Jan 1, 1997·Dysphagia·D W Buchholz, S Neumann
May 1, 1997·Southern Medical Journal·G W HornigC Tilton
Feb 12, 1998·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·R S McLachlan
Jul 22, 1998·Epilepsia·S C Schachter, C B Saper
Sep 17, 1998·Epilepsia·J LundgrenR Olsson
Apr 2, 1999·Pediatrics·A P ParkerR O Robinson
Apr 25, 2000·Seizure : the Journal of the British Epilepsy Association·C D Binnie
Sep 6, 2000·Developmental Medicine and Child Neurology·D Labar

❮ Previous
Next ❯

Citations

Jul 11, 2007·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Divya S KhuranaSanjeev V Kothare
Mar 6, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·S M R KabirJ McMullan
Nov 11, 2006·Current Psychiatry Reports·Ziad NahasMark S George
Mar 12, 2003·Current Treatment Options in Neurology·Martin C. Salinsky
Apr 16, 2003·Epilepsy & Behavior : E&B·Tracy A Glauser
Sep 1, 2004·Neurosurgery·Rahul JandialMichael L Levy
Aug 11, 2012·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Sylvia KlinkenbergAlbert P Aldenkamp
Feb 14, 2003·Mayo Clinic Proceedings·Aaron A Cohen-GadolCorey Raffel
Jan 22, 2008·Pediatric Neurology·Tauyee HsiehYemiserach Kifle
Aug 26, 2014·Acta Neurologica Scandinavica·R S FisherC W Wright
Nov 1, 2006·Pediatric Neurology·Russell P SanetoRichard G Ellenbogen
May 1, 2012·Developmental Medicine and Child Neurology·Sylvia KlinkenbergMarian Majoie
Dec 27, 2005·Epilepsy & Behavior : E&B·Evelyn S Tecoma, Vicente J Iragui
Apr 30, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Mariam Mettry HullCharles M Zaroff
Jan 12, 2005·Seizure : the Journal of the British Epilepsy Association·H J M MajoieA G H Kessels
Jul 29, 2008·Seizure : the Journal of the British Epilepsy Association·E RossignolL Carmant
Oct 17, 2012·Seizure : the Journal of the British Epilepsy Association·Guido LancmanTheodore H Schwartz
May 14, 2008·Journal of Child Neurology·Elisabeth M S ShermanKevin Farrell
Aug 9, 2019·Annals of Neurology·Karim MithaniGeorge M Ibrahim
Aug 30, 2003·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Lakshmi NagarajanSoumya Ghosh
Jul 12, 2017·Journal of Neurodevelopmental Disorders·Crystal T EngineerMichael P Kilgard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Nelia ZamponiAlessandro Ducati
Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
H J.M. MajoieW O. Renier
© 2022 Meta ULC. All rights reserved