VNTR analysis demonstrates new patterns and high genetic diversity of Leptospira sp. of animal origin in Brazil

Letters in Applied Microbiology
Lauren Hubert JaegerWalter Lilenbaum

Abstract

Leptospirosis is a worldwide zoonosis with a broad host range, including humans and domestic and wild animals. The taxonomic classification of Leptospira species is complex. More recently, several molecular tools have been employed in the attempt to group the different strains of leptospires. The objective of this study was the genetic characterization of Brazilian Leptospira sp. isolates obtained from wild and domestic animals. The genotyping of the strains was performed by the variable-number tandem repeats (VNTR) technique, using the Leptospira interrogans/Leptospira kirschneri and Leptospira santarosai protocols. A total of 27 novel strains were characterized and 22 novel VNTR patterns were described. This study suggests a high genetic diversity among the strains obtained from different wild and domestic animals, and reinforces the need for a broad approach aligned to the One Health concept for leptospirosis. Animal leptospirosis is an important cause of reproductive failure in livestock and economic losses to producing countries. This study describes several novel variable-number tandem repeats patterns and points out the high genetic diversity of Brazilian strains. Understanding the circulation of strains between animals ...Continue Reading

References

Jan 1, 1991·Journal of Bacteriology·W G WeisburgD J Lane
Jul 31, 2001·FEMS Immunology and Medical Microbiology·A de la Peña-MoctezumaB Adler
Dec 26, 2001·Bioinformatics·K A JolleyM C Maiden
Feb 8, 2005·Journal of Clinical Microbiology·Z MajedM Picardeau
Nov 8, 2006·Journal of Clinical Microbiology·Laurence SalaünMathieu Picardeau
Nov 24, 2006·Annals of Clinical Microbiology and Antimicrobials·Niyaz AhmedRudy A Hartskeerl
Sep 24, 2013·Diagnostic Microbiology and Infectious Disease·Fabiana MiragliaAndrea Micke Moreno
Aug 25, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Nobuo KoizumiMakoto Ohnishi
Sep 27, 2015·Letters in Applied Microbiology·Ana Paula LoureiroWalter Lilenbaum
Nov 1, 2015·Journal of Infection in Developing Countries·Fabiana MiragliaAndrea Micke Moreno
Feb 20, 2016·PLoS Neglected Tropical Diseases·Derrick E FoutsJoseph M Vinetz
Jun 11, 2016·Acta Tropica·Bruno Alonso MiottoMitika Kuribayashi Hagiwara
Aug 2, 2016·Journal of the American Veterinary Medical Association·Kenneth R Harkin, Michael P Hays
Jan 26, 2017·Acta Tropica·Narianne Ferreira de AlbuquerqueVânia Maria França Ribeiro

❮ Previous
Next ❯

Citations

Jul 31, 2018·Journal of Medical Microbiology·Lauren Hubert JaegerWalter Lilenbaum
Jul 26, 2019·Transboundary and Emerging Diseases·Manuel JaraGustavo Machado
Jul 31, 2019·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Cristina BarbosaWalter Lilenbaum
Nov 28, 2020·Comparative Immunology, Microbiology and Infectious Diseases·Israel Barbosa GuedesMarcos Bryan Heinemann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.