Vocal cord palsy after vincristine treatment in a child and the inefficacy of glutamic acid in the prevention of relapse: a case report.

Journal of Medical Case Reports
Piero FarruggiaPaolo D'Angelo

Abstract

Vincristine is an antineoplastic drug with a well known efficacy for the treatment of acute lymphoblastic leukemia and many solid tumors. No more than 20 pediatric patients with vincristine-induced vocal cord palsy have been reported, and to the best of our knowledge this is the first case where glutamic acid was administered with the aim of preventing a relapse of laryngeal dysfunction. The larynx paralysis presented with hoarseness and stridor in a Caucasian 18-month-old girl and spontaneously resolved in about a month. In order to administer a subsequent full dose of vincristine, our patient received oral glutamic acid whose efficacy against vincristine neurological side effects has been previously reported. Since in our patient the amino acid proved to be ineffective in the prevention of laryngeal paralysis relapse, we suggest that a dose reduction of vincristine should be preferred by oncologists as an initial approach after a case of drug-induced vocal cord palsy.

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Citations

Jan 23, 2013·International Journal of Clinical Pharmacy·Serkan Feyyaz YalinMehmet Riza Altiparmak
Mar 5, 2015·American Journal of Therapeutics·Hillary AaronMiriam N Lango
Nov 15, 2012·Current Opinion in Otolaryngology & Head and Neck Surgery·Jennifer Setlur, Christopher J Hartnick
Jan 28, 2021·The Annals of Otology, Rhinology, and Laryngology·Guy TalmorChristen Caloway
Jan 28, 2020·Seminars in Oncology Nursing·Lynn TannerJessica Sparrow

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