Vogt-Koyanagi-Harada disease during chemoimmunotherapy for non-small cell lung cancer

Respirology Case Reports
Yuri KuronoKazuki Hirose

Abstract

Vogt-Koyanagi-Harada disease (VKHD) is a rare systemic granulomatous autoimmune disease that affects melanocyte-rich organs such as eye, inner ear, meninges, skin, and hair. VKHD leads to chronic uveal inflammation accompanied by a decline in visual acuity in some patients when appropriate corticosteroid treatment was not initiated in an early phase. Immune checkpoint inhibitors (ICIs) are widely used in the treatment of several kinds of cancers and chemoimmunotherapy has become the standard of care in the first-line treatment of non-small cell lung cancer (NSCLC). While ICIs induce immune-related adverse events, drug-induced VKHD is quite rare with only four reports in the ICI monotherapy; three patients with melanoma and one patient with NSCLC. We describe the first case of VKHD during chemoimmunotherapy including pembrolizumab in a patient with NSCLC, which was successfully treated with corticosteroid without any sequela.

References

Mar 25, 2016·Orphanet Journal of Rare Diseases·Marcelo Mendes LavezzoJoyce Hisae Yamamoto
Mar 10, 2017·Expert Review of Anticancer Therapy·Omar Abdel-RahmanAnwar Giryes
May 8, 2018·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tomoki TamuraSyouichi Kuyama
Oct 4, 2018·The New England Journal of Medicine·Luis Paz-AresUNKNOWN KEYNOTE-407 Investigators

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