Voice outcomes following laser cordectomy for early glottic cancer: a physical model investigation

The Laryngoscope
Abie H MendelsohnZhaoyan Zhang

Abstract

The voice effects following laser cordectomy for early glottic cancer are poorly described. We investigated the voice outcomes of subligamentous cordectomy of progressive anterior-posterior extent of excision. Physical phonatory modeling. The influence of vocal fold surgical defects and corresponding scar was experimentally investigated using a self-oscillating physical model of the vocal folds and compared with the baseline model without defects or scar. Results showed that increasing anterior-posterior extent of resection increased phonation threshold pressure and flow rate and reduced excitation of high-order harmonics, resulting in a more breathy and rough voice production. However, it was found that voice production was improved with the placement of scar, which increased both excitation of high-order harmonics and the harmonic-to-noise ratio. Although large anterior-posterior surgical resections resulted in progressive impact on vocal measures, a limited excision of the vocal fold cover surprisingly demonstrated minimal voice changes. Further investigations are required to define the acceptable extent of surgical resection that may result in optimal voice outcomes.

References

Jun 27, 2000·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·M RemacleT P Wustrow
Sep 29, 2006·The Journal of the Acoustical Society of America·Zhaoyan ZhangDavid A Berry
Jul 20, 2007·Head & Neck·Isabel VilasecaManuel Bernal-Sprekelsen
Feb 12, 2009·The Journal of the Acoustical Society of America·Zhaoyan Zhang
Apr 8, 2010·The Journal of the Acoustical Society of America·Zhaoyan Zhang
Nov 18, 2011·The Journal of the Acoustical Society of America·Abie H Mendelsohn, Zhaoyan Zhang
Feb 9, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Christine D L van GoghHans F Mahieu
Jan 10, 2013·The Journal of the Acoustical Society of America·Zhaoyan ZhangMarc Garellek
Apr 13, 2013·The Annals of Otology, Rhinology, and Laryngology·Alexander T HillelAdam M Klein

❮ Previous
Next ❯

Citations

Jun 23, 2015·Otolaryngologic Clinics of North America·Chad W Whited, Seth H Dailey
Jun 23, 2015·Otolaryngologic Clinics of North America·Dana M HartlDaniel F Brasnu
Nov 9, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·William M MendenhallAlfio Ferlito
Mar 18, 2017·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Seung Yeun ChungChang Geol Lee
Oct 22, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Sachin GandhiShraddha Jayant Saindani
Mar 9, 2021·Journal of Voice : Official Journal of the Voice Foundation·Carlos CalvacheLina Peñuela

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of the Acoustical Society of America
Abie H Mendelsohn, Zhaoyan Zhang
Brazilian Journal of Otorhinolaryngology
Leonardo HaddadFernando Danelon Leonhardt
Journal of the Formosan Medical Association = Taiwan Yi Zhi
Tyng-Guey WangTzu-Yu Hsiao
The Annals of Otology, Rhinology, and Laryngology
David A BerryCharles N Ford
European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Faustino Núñez BatallaCarlos Suárez Nieto
© 2021 Meta ULC. All rights reserved