Voided urine fluorescence in situ hybridization testing for upper tract urothelial carcinoma surveillance

The Journal of Urology
James R JohannesDemetrius H Bagley

Abstract

Fluorescence in situ hybridization is gaining popularity for transitional cell carcinoma screening. We determined the accuracy of fluorescence in situ hybridization for identifying upper tract transitional cell carcinoma. A retrospective review of our upper tract transitional cell carcinoma database from 2005 to 2008 identified 35 patients with upper tract transitional cell carcinoma who submitted voided urine specimens for fluorescence in situ hybridization at commercial laboratory during a routine office visit. Each patient was evaluated endoscopically in the operating room within 3 months of sampling. Suspicious lesions were biopsied and treated. Transitional cell carcinoma in the lower or upper tract was proved by direct visualization, positive biopsy or upper tract cytology read as positive or highly suspicious for malignancy. Of the patients 35 satisfied study inclusion criteria. A total of 67 fluorescence in situ hybridization specimens were submitted. Upper tract transitional cell carcinoma was identified on 51 operative evaluations, of which 23 showed concurrent bladder tumor. For all encounters the sensitivity of fluorescence in situ hybridization was 56% and specificity was 80%. Sensitivity for low and high grade les...Continue Reading

References

Apr 21, 1999·The Journal of Urology·C MianM Marberger
Jul 13, 2001·American Journal of Clinical Pathology·L BubendorfP Dalquen
Mar 14, 2002·Journal of Endourology·David LeeDemetrius Bagley
Oct 25, 2002·Journal of Endourology·David P MurphyStevan B Streem
Aug 6, 2003·Critical Reviews in Oncology/hematology·Ziya Kirkali, Emre Tuzel
Mar 26, 2004·The Urologic Clinics of North America·John S Lam, Mantu Gupta
Jul 13, 2004·European Urology·W OosterlinckUNKNOWN European Association of Urology
Jun 1, 2005·European Urology·Bas W G van RhijnTheo H van der Kwast
Sep 30, 2005·Journal of Endourology·Khai-Linh V Ho, George K Chow
Apr 29, 2008·The British Journal of Radiology·E J Hall, D J Brenner

❮ Previous
Next ❯

Citations

Aug 27, 2011·Therapeutic Advances in Urology·Mesut RemziChristian Seitz
Aug 26, 2014·Der Urologe. Ausg. A·S RauschA Stenzl
Sep 13, 2013·Der Urologe. Ausg. A·M BöhmUNKNOWN Arbeitskreis Urinzytologie der DGU (Deutsche Gesellschaft für Urologie)
Jan 9, 2014·Urologic Oncology·Surena F MatinArthur P Grollman
Nov 1, 2011·Actas urologicas españolas·M RouprêtUNKNOWN European Association of Urology Guideline Group for urothelial cell carcinoma of the upper urinary tract
Apr 2, 2013·European Urology·Morgan RouprêtUNKNOWN European Association of Urology
Feb 27, 2016·Cytopathology : Official Journal of the British Society for Clinical Cytology·F MaltaP Mikou
Dec 14, 2016·Nature Reviews. Urology·Joyce BaardM Pilar Laguna
Jul 6, 2011·Nature Reviews. Urology·Thomas F ChromeckiShahrokh F Shariat
Jan 13, 2015·International Journal of Immunopathology and Pharmacology·R MazzucchelliR Montironi
Nov 23, 2016·Cytopathology : Official Journal of the British Society for Clinical Cytology·M Courtade-SaïdiL Lacoste-Collin
Aug 15, 2020·Journal of the American Society of Cytopathology : JASC·M Lisa ZhangPoonam Vohra
Jul 1, 2021·Investigative and Clinical Urology·Jason M FarrowChandru P Sundaram

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.