Volatile Anesthetic Sevoflurane Attenuates Toll-Like Receptor 1/2 Activation.

Anesthesia and Analgesia
Yusuke MitsuiKoichi Yuki

Abstract

Although immunomodulatory effects of anesthetics have been increasingly recognized, their underlying molecular mechanisms are not completely understood. Toll-like receptors (TLRs) are one of the major receptors to recognize invading pathogens and danger signals from damaged host tissues to initiate immune responses. Among the TLR family, TLR2 and TLR4 recognize a wide range of ligands and are considered to be important players in perioperative pathophysiology. Based on our recent finding that volatile anesthetics modulate TLR4 function, we tested our hypothesis that they would also modulate TLR2 function. The effect of anesthetics isoflurane, sevoflurane, propofol, and dexmedetomidine on TLR2 activation was examined by reporter assays. An anesthetic that affected the activation was subjected to in silico rigid docking simulation on TLR2. To test our prediction that sevoflurane and a TLR1/TLR2 ligand Pam3CSK4 would compete for the same pocket of TLR2, we performed Pam3CSK4 competitive binding assay to TLR2 using HEK cells stably transfected with TLR2 (HEK-TLR2) with or without sevoflurane. We examined the effect of different anesthetics on the functions of human neutrophils stimulated with TLR2 ligands. Kruskal-Wallis test and M...Continue Reading

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Citations

Sep 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sophia KoutsogiannakiKoichi Yuki
Sep 15, 2020·Cancer Management and Research·Xiaoqing FanRuiting Wang
Nov 21, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Koichi YukiSulpicio G Soriano
Nov 24, 2020·The Journal of Surgical Research·Miho Shibamura-FujiogiKoichi Yuki
Mar 26, 2021·BioMed Research International·Koichi Yuki, Miho Shibamura-Fujiogi
Apr 25, 2021·Biochemical and Biophysical Research Communications·Koichi YukiSophia Koutsogiannaki
May 3, 2021·International Immunopharmacology·Koichi Yuki

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