Volatile-based short-term sedation in cardiac surgical patients: a prospective randomized controlled trial

Critical Care Medicine
Angela JerathPerioperative Anesthesia Clinical Trials Group

Abstract

To evaluate the differences in extubation times in a group of cardiac surgical patients who were anesthetized and sedated with either IV propofol or inhaled volatile anesthetic agents. This was a prospective randomized controlled trial performed between September 2009 and August 2011. Cardiovascular ICU within a tertiary referral university-affiliated teaching hospital. One hundred forty-one patients undergoing coronary artery bypass graft surgery with normal or mildly reduced left ventricular systolic function. Participants were randomly assigned to receive anesthesia and postoperative sedation using IV propofol (n = 74) or inhaled volatile (isoflurane or sevoflurane) anesthetic agent (n = 67). Patients sedated using inhaled volatile agent displayed faster readiness to extubation time at 135 minutes (95-200 min) compared with those receiving IV propofol at 215 minutes (150-280 min) (p < 0.001). Extubation times were faster within the volatile group at 182 minutes (140-255 min) in comparison with propofol group at 291 minutes (210-420 min) (p < 0.001). The volatile group showed a higher prevalence of vasodilatation with hypotension and higher cardiac outputs necessitating greater use of vasoconstrictors. There was no difference...Continue Reading

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Citations

May 31, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Giovanni LandoniAlberto Zangrillo
Mar 24, 2016·American Journal of Respiratory and Critical Care Medicine·Angela JerathNiall D Ferguson
Dec 17, 2016·Anesthesia and Analgesia·Hong LiuNeal Fleming
Apr 26, 2017·Critical Care Medicine·Stefano RomagnoliA Raffaele De Gaudio
Dec 12, 2017·International Anesthesiology Clinics·Ameeka Pannu, Brian O'Gara
Sep 2, 2017·Journal of Clinical Monitoring and Computing·Jennifer Herzog-NiesceryMartin Bellgardt
Jan 27, 2017·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Adrian WongSarah Day
Jun 27, 2020·Intensive Care Medicine·Angela JerathBrian Cuthbertson
May 8, 2020·Anaesthesia Critical Care & Pain Medicine·Florian BlanchardJean-Michel Constantin
Nov 3, 2020·Critical Care Explorations·Armin Niklas FlinspachElisabeth Hannah Adam
Dec 8, 2021·Current Opinion in Anaesthesiology·Benu MakkadMiklos D Kertai

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