Volatile biomarkers of pulmonary tuberculosis in the breath

Tuberculosis
Michael PhillipsOlaf Tietje

Abstract

Pulmonary tuberculosis may alter volatile organic compounds (VOCs) in breath because Mycobacteria and oxidative stress resulting from Mycobacterial infection both generate distinctive VOCs. The objective of this study was to determine if breath VOCs contain biomarkers of active pulmonary tuberculosis. Head space VOCs from cultured Mycobacterium tuberculosis were captured on sorbent traps and assayed by gas chromatography/mass spectroscopy (GC/MS). One hundred and thirty different VOCs were consistently detected. The most abundant were naphthalene, 1-methyl-, 3-heptanone, methylcyclododecane, heptane, 2,2,4,6,6-pentamethyl-, benzene, 1-methyl-4-(1-methylethyl)-, and cyclohexane, 1,4-dimethyl-. Breath VOCs were assayed by GC/MS in 42 patients hospitalized for suspicion of pulmonary tuberculosis and in 59 healthy controls. Sputum cultures were positive for Mycobacteria in 23/42 and negative in19/42 patients. Breath markers of oxidative stress were increased in all hospitalized patients (p<0.04). Pattern recognition analysis and fuzzy logic analysis of breath VOCs independently distinguished healthy controls from hospitalized patients with 100% sensitivity and 100% specificity. Fuzzy logic analysis identified patients with positive...Continue Reading

References

Sep 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J J ParezF Pouthier
Jul 20, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·M PhillipsR N Cataneo
Sep 14, 2000·The Journal of Laboratory and Clinical Medicine·M PhillipsF Rahbari-Oskoui
Apr 26, 2003·Heart Disease·Michael PhillipsManuel Salazar
May 20, 2003·The Breast Journal·Michael PhillipsCynthia Wong
Jun 11, 2003·Chest·Michael PhillipsWilliam N Rom
Dec 18, 2003·Seminars in Respiratory Infections·Neil W Schluger
Apr 10, 2004·Respiratory Medicine·Pawel ChomejUlrich Sack
May 20, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Michael PhillipsJoel Greenberg
May 29, 2004·American Journal of Obstetrics and Gynecology·Michael MorettiJoel Greenberg
Sep 16, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Michael PhillipsMark J Zucker

❮ Previous
Next ❯

Citations

Apr 2, 2014·International Journal of Medical Sciences·Shahaboddin ShamshirbandMiss Laiha Mat Kiah
Apr 25, 2014·Analytica Chimica Acta·Corrado Di NataleRosamaria Capuano
Aug 9, 2007·Future Microbiology·Nabin K Shrestha
Apr 9, 2011·Biomarkers in Medicine·Aron ChakeraMichaela Lucas
Feb 1, 2014·Archives of Microbiology·Srinivasan VijayParthasarathi Ajitkumar
Jun 25, 2014·Metabolites·Célia Lourenço, Claire Turner
Dec 11, 2013·Bioanalysis·Ngoc A DangArend H J Kolk
Sep 8, 2010·Radiation and Environmental Biophysics·C BrunnerU Oeh
Aug 20, 2010·Journal of Clinical Microbiology·Arend KolkKlaus Reither
Apr 13, 2011·Clinical Microbiology Reviews·Linda M ParsonsJohn Nkengasong
Apr 29, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Joanna Kałużna-Czaplińska
Jul 5, 2013·Clinical Microbiology Reviews·Shneh SethiTrinad Chakraborty
Sep 11, 2012·Malaria Journal·Rina P M WongTimothy M E Davis
Dec 25, 2012·Respiratory Research·Kim D G van de KantEdward Dompeling
Aug 30, 2007·The Journal of Infectious Diseases·Mark D Perkins, Jane Cunningham
Jul 21, 2011·Journal of Biochemistry·Mika Shirasu, Kazushige Touhara
Oct 22, 2009·Analytical and Bioanalytical Chemistry·Audrey N MartinMatthias Frank
Oct 16, 2010·Advanced Powder Technology : the International Journal of the Society of Powder Technology, Japan·Alquam Mashir, Raed A Dweik
Nov 26, 2010·Pulmonary Pharmacology & Therapeutics·Clive Page
Dec 22, 2010·Paediatric Respiratory Reviews·Mark P Nicol, Heather J Zar
Mar 2, 2010·Tuberculosis·Michael PhillipsJames Wai
Oct 27, 2015·BioMed Research International·Azian Azamimi AbdullahShigehiko Kanaya
Apr 19, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Michael PhillipsJames Wai
Feb 26, 2008·Tuberculosis·Mona Syhre, Stephen T Chambers
Jun 3, 2015·Biomedical Chromatography : BMC·Amir Abd El QaderYehuda Zeiri
May 25, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Alexis N ThomasArdeshir Bayat
Mar 29, 2011·Letters in Applied Microbiology·S U SavelevA De Soyza
Jul 19, 2012·Journal of Forensic Sciences·Maiko KusanoKenneth G Furton
Apr 11, 2014·Chembiochem : a European Journal of Chemical Biology·Alexander A AksenovCristina E Davis
Mar 5, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Christoph Lange, Toru Mori
Jul 30, 2010·IEEE Transactions on Bio-medical Engineering·Dongmin GuoJianhua Yang
Jun 23, 2015·Electrophoresis·Gisele A B CanutoMarina F M Tavares
Jul 21, 2015·Infectious Disease Clinics of North America·Silvia S ChiangJeffrey R Starke
Oct 24, 2013·BioMed Research International·Attapon Cheepsattayakorn, Ruangrong Cheepsattayakorn
Nov 21, 2009·Clinics in Chest Medicine·T Mark DohertyAlimuddin Zumla
Nov 13, 2009·Respiratory Medicine·J J B N Van BerkelF J Van Schooten
May 5, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mandeep S Jassal, Grace M Aldrovandi
Nov 7, 2012·Tuberculosis·Marcel BruinsAlex van Belkum
Jun 1, 2012·Tuberculosis·Michael PhillipsZarir F Udwadia
Sep 1, 2015·Journal of Biomarkers·Kamila Schmidt, Ian Podmore
Jan 10, 2012·FEMS Microbiology Letters·Ruth McNerneyClaire Turner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.