Volatile organic compounds and risk of asthma and allergy: a systematic review

European Respiratory Review : an Official Journal of the European Respiratory Society
Ulugbek B NurmatovAziz Sheikh

Abstract

Volatile organic compounds (VOCs) are ubiquitous domestic pollutants. Their role in asthma/allergy development and exacerbations is uncertain. This systematic review investigated whether domestic VOC exposure increases the risk of developing and/or exacerbating asthma and allergic disorders. We systematically searched 11 databases and three trial repositories, and contacted an international panel of experts to identify published and unpublished experimental and epidemiological studies. 8455 potentially relevant studies were identified; 852 papers were removed after de-duplication, leaving 7603 unique papers that were screened. Of these, 278 were reviewed in detail and 53 satisfied the inclusion criteria. Critical appraisal of the included studies indicated an overall lack of high-quality evidence and substantial risk of bias in this body of knowledge. Aromatics (i.e. benzenes, toluenes and xylenes) and formaldehyde were the main VOC classes studied, both in relation to the development and exacerbations of asthma and allergy. Approximately equal numbers of studies reported that exposure increased risks and that exposure was not associated with any detrimental effects. The available evidence implicating domestic VOC exposure in t...Continue Reading

References

Aug 1, 1990·Environmental Research·M KrzyzanowskiM D Lebowitz
Jun 1, 1995·Occupational and Environmental Medicine·D NorbäckG Boman
Jan 6, 1996·BMJ : British Medical Journal·M Omran, G Russell
Jan 1, 1997·International Archives of Occupational and Environmental Health·G WieslanderG Boman
Mar 29, 2000·Archives of Environmental Health·G Smedje, D Norbäck
Feb 9, 2002·International Journal of Hygiene and Environmental Health·I LehmannUNKNOWN Leipzig Allergy Risk Children Study
Sep 6, 2002·The European Respiratory Journal·K B RumchevS M Stick
Feb 6, 2004·British Medical Bulletin·Junfeng Zhang, Kirk R Smith
Feb 14, 2004·The Australasian Journal of Dermatology·Nicole JennerRobin Marks
Jul 21, 2004·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Robert Dales, Mark Raizenne
Sep 30, 2005·Archives of Environmental Health·Tuula PutusSirpa Rautiala
Feb 24, 2006·International Journal of Hygiene and Environmental Health·Olf HerbarthUwe Schlink
Mar 9, 2006·The Journal of Allergy and Clinical Immunology·Gaël TavernierRobert Niven
Sep 5, 2006·Thorax·R GuptaH R Anderson
Dec 19, 2006·Toxicology Letters·Hidekazu FujimakiKeiichi Arashidani
Mar 16, 2007·International Archives of Occupational and Environmental Health·Ahmed A Arif, Syed M Shah
May 8, 2007·Toxicology and Applied Pharmacology· Tin-Tin-Win-ShweHidekazu Fujimaki
Nov 2, 2007·Environmental Monitoring and Assessment·Pui-Shan HuiLing-Tim Wong
Nov 17, 2007·Paediatric Respiratory Reviews·Peter J Franklin
Dec 8, 2007·Annals of Epidemiology·Ichiro MatsunagaUNKNOWN Osaka Maternal and Child Health Study Group
Jan 18, 2008·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·J C LeeJ C Kim
Jan 29, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Zhuohui ZhaoDan Norbäck
Sep 10, 2008·Journal of the Royal Society of Medicine·Nazim GhouriAziz Sheikh
Nov 26, 2008·Journal of the Royal Society of Medicine·Colin R SimpsonAziz Sheikh
Feb 12, 2009·Pediatric Pulmonology·Virginia Fuentes-LeonarteFerran Ballester
May 14, 2009·Journal of Environmental Monitoring : JEM·Piero LovreglioLeonardo Soleo
Dec 24, 2009·Indoor Air·O Raaschou-NielsenH Bisgaard
Mar 5, 2010·Journal of the Royal Society of Medicine·Colin R Simpson, Aziz Sheikh
Aug 18, 2010·Health Information and Libraries Journal·Sergei V Jargin

❮ Previous
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Citations

Sep 25, 2015·Toxins·Joan W Bennett, Arati A Inamdar
May 11, 2016·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Inês PaciênciaEduardo de Oliveira Fernandes
Jul 20, 2016·Journal of Immunotoxicology·Jitka S HansenSøren Thor Larsen
Jan 13, 2017·American Journal of Industrial Medicine·Randall J NettKathleen Kreiss
Jan 28, 2017·Environment International·Peder Wolkoff, Gunnar D Nielsen
Jul 10, 2018·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Jean LevyGabriel Thabut
Feb 27, 2019·Clinical Reviews in Allergy & Immunology·Yasmin HassounDavid I Bernstein
Mar 8, 2019·Reviews on Environmental Health·Alexandra N DavisJane A McElroy
Jun 27, 2019·Environmental Toxicology·Seong-Gyeol HongSung-Tae Yee
Mar 8, 2020·International Journal of Environmental Research and Public Health·Giulia SquillaciotiRoberto Bono
Jul 15, 2020·Expert Review of Respiratory Medicine·Benedetta BiagioniLorenzo Cecchi
Sep 4, 2020·International Journal of Epidemiology·Mary WillisElaine Hill
Jan 6, 2017·Environmental Science and Pollution Research International·Gea Oliveri ContiMargherita Ferrante
May 4, 2017·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Irina Lehmann
Aug 9, 2018·Environmental Health : a Global Access Science Source·Jae-Woo KwonSeung-Joon Lee
Jun 28, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Dina Hashoul, Hossam Haick
Oct 12, 2018·Allergy, Asthma & Immunology Research·Dong Keon YonMan Yong Han
Sep 24, 2019·Journal of Toxicology and Environmental Health. Part a·Mauro PetrettaLivia Roseti
Sep 26, 2020·International Journal of Environmental Research and Public Health·Raquel Rodrigues Dos SantosAna S Fernandes
Feb 6, 2017·Allergologia et immunopathologia·D GuptaS S Sandhu
Jan 16, 2021·The European Respiratory Journal·Dan Norbäck, Juan Wang
Jan 16, 2021·Environmental Science & Technology·Tianren WuBrandon E Boor
Feb 11, 2021·International Journal of Environmental Research and Public Health·Kyle L Alford, Naresh Kumar
Feb 13, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·D CaimmiP Demoly
Feb 12, 2021·International Journal of Molecular Sciences·Chih-Hsing HungWei-Ting Liao
Jan 22, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Nikolaos G PapadopoulosParaskevi Xepapadaki
Apr 3, 2021·Environment International·Patrice SuttonTracey J Woodruff
Jun 18, 2021·Regulatory Toxicology and Pharmacology : RTP·Emanoela Lundgren TháDaniela Morais Leme
Mar 23, 2021·Arthritis & Rheumatology·Federica MaritatiAugusto Vaglio
Jun 28, 2018·Environmental Science & Technology·Pawel K MisztalAllen H Goldstein
Dec 16, 2020·Journal of the American Chemical Society·Qingyue WangKing Lun Yeung
Jun 17, 2020·The Science of the Total Environment·Ramen Munir BalochUNKNOWN SINPHONIE Study group

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