Volatility Facilitates Value Updating in the Prefrontal Cortex

Neuron
Bart MassiDaeyeol Lee

Abstract

Adaptation of learning and decision-making might depend on the regulation of activity in the prefrontal cortex. Here we examined how volatility of reward probabilities influences learning and neural activity in the primate prefrontal cortex. We found that animals selected recently rewarded targets more often when reward probabilities of different options fluctuated across trials than when they were fixed. Additionally, neurons in the orbitofrontal cortex displayed more sustained activity related to the outcomes of their previous choices when reward probabilities changed over time. Such volatility also enhanced signals in the dorsolateral prefrontal cortex related to the current but not the previous location of the previously rewarded target. These results suggest that prefrontal activity related to choice and reward is dynamically regulated by the volatility of the environment and underscore the role of the prefrontal cortex in identifying aspects of the environment that are responsible for previous outcomes and should be learned.

Citations

May 31, 2019·Nature Reviews. Neuroscience·Alireza Soltani, Alicia Izquierdo
Sep 11, 2019·Nature Human Behaviour·Shiva FarashahiAlireza Soltani
Dec 19, 2019·ELife·Jennifer L CookRoshan Cools
May 18, 2019·Science·Morteza Sarafyazd, Mehrdad Jazayeri
Oct 13, 2020·Frontiers in Psychology·Kajornvut OunjaiJohan Lauwereyns
Dec 2, 2020·ELife·Jing WangMehrdad Jazayeri
Nov 18, 2020·ELife·Bastien Blain, Robb B Rutledge
Oct 27, 2020·ELife·Henry Wp DalgleishMichael Häusser
Jan 8, 2021·Frontiers in Neural Circuits·Sean E CavanaghSteven W Kennerley
May 25, 2021·Current Opinion in Behavioral Sciences·Alireza SoltaniDaeyeol Lee
Aug 15, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alireza Soltani, Etienne Koechlin
Aug 20, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Peter H Rudebeck, Alicia Izquierdo

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