PMID: 6965707Jan 1, 1980Paper

Voltage clamp study of fast excitatory synaptic currents in bullfrog sympathetic ganglion cells

The Journal of General Physiology
A B MacDermottR L Parsons

Abstract

Excitatory postsynaptic currents (EPSCs) have been studied in voltage-clamped bullfrog sympathetic ganglion B cells. The EPSC was small, rose to a peak within 1-3 ms, and then decayed exponentially over most of its time-course. For 36 cells at --50 mV (21-23 degrees C), peak EPSC size was --6.5 +/- 3.5 nA (mean +/- SD), and the mean decay time constant tau was 5.3 +/- 0.9 ms. tau showed a small negative voltage dependence, which appeared independent of temperature, over the range --90 to --30 mV; the coefficient of voltage dependence was --0.0039 +/-0.0014 mV-1 (n = 29). The peak current-voltage relationship was linear between --120 and --30 mV but often deviated from linearity at more positive potentials. The reversal potential determined by interpolation was approximately --5 mV. EPSC decay tau had a Q10 = 3. The commonly used cholinesterase inhibitors, neostigmine and physostigmine, exhibited complex actions at the ganglia. Neostigmine (1 X 10(-5)M) produced a time-dependent slowing of EPSC decay without consistent change in EPSC size. In addition, the decay phase often deviated from a single exponential function, although it retained its negative voltage dependence. With 1 x 10(-6) M physostigmine, EPSC decay was slowed by ...Continue Reading

References

Oct 19, 1977·Pflügers Archiv : European journal of physiology·J Dudel
Jun 10, 1977·Brain Research·H A Weitsen, F F Weight
Nov 1, 1974·The Journal of General Physiology·R LlinásC Nicholson
Jan 1, 1974·Pflügers Archiv : European journal of physiology·J Dudel
Aug 1, 1965·Journal of Cellular Physiology·S NishiK Koketsu
Jan 1, 1958·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J C ECCLES, J C JAEGER
Feb 16, 1965·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B KATZ, R MILEDI
Feb 1, 1960·Journal of Cellular and Comparative Physiology·S NISHI, K KOKETSU

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Citations

Jan 1, 1984·Pflügers Archiv : European journal of physiology·D C OgdenH P Rang
Dec 9, 1982·Brain Research·B Apatoff, W K Riker
Jan 1, 1987·Progress in Neurobiology·M L Mayer, G L Westbrook
Jul 1, 1994·Progress in Neurobiology·P A Smith
Apr 1, 1995·Progress in Neurobiology·T Akasu, T Nishimura
Mar 1, 1983·Neuroscience·E KatoT Narahashi
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R E Study, J L Barker
Feb 1, 1983·British Journal of Pharmacology·E A Connor, R L Parsons
Oct 1, 1983·British Journal of Pharmacology·P T Gray, H P Rang
Sep 2, 1985·Brain Research·G G SchofieldM Adler
Dec 22, 1983·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·P T Gray, C J Magnus
Nov 23, 1987·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A MathieD Colquhoun

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