Voltage-controlled plasticity at GluR2-deficient synapses onto hippocampal interneurons

Journal of Neurophysiology
Fernanda Laezza, Raymond Dingledine

Abstract

High-frequency stimulation of pyramidal cell inputs to developing (P9-12) hippocampal stratum radiatum interneurons expressing GluR2-lacking, Ca(2+)-permeable AMPA receptors produces long-term depression of synaptic transmission, if N-methyl-d-aspartate (NMDA) receptors are blocked. Here we show that these same synapses display a remarkably versatile signal integration if postsynaptic NMDA receptors are activated. At synapses expressing GluR2-deficient AMPA receptors, tetanic stimulation that activates NMDA receptors triggered long-term potentiation or depression (LTP or LTD) depending on membrane potential. LTP was elicited at most synapses when the interneuron was held at -30 mV during the stimulus train but was typically prevented by postsynaptic hyperpolarization to -70 mV, by strong depolarization to 0 mV, by d-2-amino-5-phosphonovaleric acid, or by postsynaptic injection of the Ca2+ chelator bis-(o-aminophenoxy)-N,N,N',N'-tetraacetic acid. At synapses with predominantly GluR2-containing AMPA receptors, repetitive stimulation did not change synaptic strength regardless of whether NMDA receptors were activated. The interactions among GluR2 expression, NMDA receptor expression, and membrane potential thus confer on hippocamp...Continue Reading

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Citations

Aug 10, 2006·Cell and Tissue Research·Rolf Sprengel
Aug 21, 2007·Nature Reviews. Neuroscience·Dimitri M Kullmann, Karri P Lamsa
Jun 6, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eric S GuireVictor A Derkach
Jan 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Iris OrenKarri P Lamsa
Jan 29, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wiebke NissenKarri P Lamsa
Apr 15, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Caroline Le Duigou, Dimitri M Kullmann
Jun 4, 2011·Current Opinion in Neurobiology·Dimitri M Kullmann
Dec 28, 2010·Neuropharmacology·Dimitri M Kullmann, Karri P Lamsa
Jan 5, 2011·Neuropharmacology·Fernanda Laezza, Raymond Dingledine
Oct 27, 2015·Frontiers in Synaptic Neuroscience·Thomas M BartolMary B Kennedy
May 29, 2009·The European Journal of Neuroscience·Ilse RiebeEric Hanse
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Jun 18, 2010·Journal of Neurophysiology·Kwang-Hyun ChoDuck-Joo Rhie
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Jun 22, 2021·Frontiers in Neural Circuits·Eve HonoréJean-Claude Lacaille

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