PMID: 16518073Mar 7, 2006Paper

Voltage-dependent Ca2+-channel block by openers of intermediate and small conductance Ca2+-activated K+ channels in urinary bladder smooth muscle cells

Journal of Pharmacological Sciences
Kozo MorimuraYuji Imaizumi

Abstract

We examined effects of small and intermediate conductance Ca(2+)-activated K(+) (SK and IK) channel openers, DCEBIO (5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one) and NS309 (3-oxime-6,7-dichloro-1H-indole-2,3-dione), on L-type Ca(2+) channel current (I(Ca)) that was measured in smooth muscle cells isolated from mouse urinary bladder under whole cell voltage-clamp. The I(Ca) was concentration-dependently inhibited by DCEBIO and NS309; half inhibition was obtained at 71.6 and 10.6 muM, respectively. The specificity of NS309 to the IK channel over the Ca(2+) channel appears to be high and higher than that of DCEBIO. DCEBIO and even NS309 may, however, substantially block Ca(2+) channels when used as SK channel openers.

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Citations

Jul 23, 2013·Pflügers Archiv : European journal of physiology·Li-Mei ZhaoXiu-Ling Deng
Sep 22, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Fernanda R C GiachiniRita C Tostes
Nov 14, 2012·British Journal of Pharmacology·Shankar P ParajuliGeorgi V Petkov
Dec 18, 2009·British Journal of Pharmacology·E BrøndumChristian Aalkjaer
Dec 17, 2008·Journal of Pharmacological Sciences·Kiyoaki KobayashiMasayuki Miyabe
Jun 15, 2007·Current Opinion in Urology·Donna J Sellers, Neil McKay
Jan 9, 2010·Expert Opinion on Therapeutic Targets·Ralf KöhlerHeike Wulff
May 1, 2010·Expert Review of Clinical Pharmacology·Heike Wulff, Neil A Castle
Jun 4, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bingxian WangWolfgang A Kunze
Dec 31, 2009·The Journal of Pharmacology and Experimental Therapeutics·Rob H P HilgersJo G R De Mey
Jul 7, 2020·American Journal of Physiology. Renal Physiology·John Malysz, Georgi V Petkov
Jun 22, 2010·Expert Opinion on Therapeutic Targets·Thomas DalsgaardUlf Simonsen
Feb 2, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Christel KroigaardUlf Simonsen
Oct 11, 2017·Frontiers in Pharmacology·Simon G Comerma-SteffensenUlf Simonsen

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