Voltage-gated divalent currents in descending vasa recta pericytes.

American Journal of Physiology. Renal Physiology
Zhong ZhangThomas L Pallone

Abstract

Multiple voltage-gated Ca(2+) channel (Ca(V)) subtypes have been reported to participate in control of the juxtamedullary glomerular arterioles of the kidney. Using the patch-clamp technique, we examined whole cell Ca(V) currents of pericytes that contract descending vasa recta (DVR). The dihydropyridine Ca(V) agonist FPL64176 (FPL) stimulated inward Ca(2+) and Ba(2+) currents that activated with threshold depolarizations to -40 mV and maximized between -20 and -10 mV. These currents were blocked by nifedipine (1 μM) and Ni(2+) (100 and 1,000 μM), exhibited slow inactivation, and conducted Ba(2+) > Ca(2+) at a ratio of 2.3:1, consistent with "long-lasting" L-type Ca(V). In FPL, with 1 mM Ca(2+) as charge carrier, Boltzmann fits yielded half-maximal activation potential (V(1/2)) and slope factors of -57.9 mV and 11.0 for inactivation and -33.3 mV and 4.4 for activation. In the absence of FPL stimulation, higher concentrations of divalent charge carriers were needed to measure basal currents. In 10 mM Ba(2+), pericyte Ca(V) currents activated with threshold depolarizations to -30 mV, were blocked by nifedipine, exhibited voltage-dependent block by diltiazem (10 μM), and conducted Ba(2+) > Ca(2+) at a ratio of ∼2:1. In Ca(2+), Bol...Continue Reading

References

Oct 1, 1992·The American Journal of Physiology·S Y ChouJ G Porush
Nov 11, 1992·The American Journal of Physiology·S LuA W Cowley
Jul 1, 1991·American Journal of Hypertension·D J Triggle
Oct 1, 1989·The American Journal of Physiology·R LoutzenhiserM Epstein
Mar 1, 1983·Journal of Cardiovascular Pharmacology·Y AbeK Yamamoto
Feb 1, 1994·The American Journal of Physiology·D V GordienkoM S Goligorsky
Nov 1, 1993·The American Journal of Physiology·P K CarminesP D Bell
Jan 1, 1994·The Journal of Clinical Investigation·T L PalloneR L Jamison
Mar 1, 1996·Hypertension Research : Official Journal of the Japanese Society of Hypertension·K HayashiT Saruta
Apr 8, 1998·The American Journal of Physiology·B M Iversen, W J Arendshorst
Apr 1, 1997·Journal of the American Society of Nephrology : JASN·E W InschoJ D Imig
Apr 25, 2000·Neuron·E A ErtelW A Catterall
May 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Z ZhangT L Pallone
Oct 26, 2001·Journal of Hypertension·M HondaT Saruta
May 9, 2002·American Journal of Physiology. Renal Physiology·Thomas L Pallone, James M-C Huang
Sep 10, 2002·American Journal of Physiology. Renal Physiology·Kristie RhinehartThomas L Pallone
Sep 14, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zhong ZhangThomas L Pallone
Sep 21, 2002·Circulation Research·Jeffrey G DickhoutAllen W Cowley
Dec 10, 2002·Annual Review of Physiology·William A Sather, Edwin W McCleskey
Dec 31, 2002·Physiological Reviews·Edward Perez-Reyes
Jun 26, 2003·The Journal of Physiology·Ian Findlay
Jul 31, 2003·Methods in Molecular Medicine·Thomas L Pallone
Oct 30, 2003·American Journal of Physiology. Renal Physiology·Ming-Guo FengL Gabriel Navar
Dec 6, 2003·Pharmacological Reviews·William A CatterallUNKNOWN International Union of Pharmacology
Mar 6, 2004·Journal of Bioenergetics and Biomembranes·Anne Marie R Yunker, Maureen W McEnery
Mar 9, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Boye L JensenOle Skøtt
Apr 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Zhong ZhangThomas L Pallone
Aug 19, 2004·American Journal of Physiology. Renal Physiology·Thomas L PalloneZhong Zhang
Jan 4, 2005·American Journal of Nephrology·Ming-Guo Feng, L Gabriel Navar
Jun 25, 2005·The Journal of Physiology·Zhong ZhangThomas L Pallone
Jul 29, 2005·American Journal of Physiology. Renal Physiology·Chunhua CaoThomas L Pallone
Nov 3, 2005·American Journal of Physiology. Renal Physiology·Ming-Guo Feng, L Gabriel Navar
Nov 19, 2005·Journal of Pharmacological Sciences·Koichi HayashiTakao Saruta
Jun 17, 2006·Cell Calcium·Karel Talavera, Bernd Nilius
Jul 15, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Qingli ZhangThomas L Pallone

❮ Previous
Next ❯

Citations

Jan 18, 2013·American Journal of Physiology. Cell Physiology·Gabriela CampanholleJeremy S Duffield
Nov 5, 2013·Current Pathobiology Reports·Naoki Nakagawa, Jeremy S Duffield
Nov 5, 2013·American Journal of Physiology. Heart and Circulatory Physiology·John J RehoSteven A Fisher
Jan 2, 2014·American Journal of Physiology. Renal Physiology·Zhong ZhangThomas L Pallone
Aug 18, 2017·American Journal of Physiology. Renal Physiology·Zhong ZhangThomas L Pallone
May 3, 2014·American Journal of Physiology. Renal Physiology·Zhong ZhangThomas L Pallone
May 24, 2013·American Journal of Physiology. Renal Physiology·Zhong ZhangThomas L Pallone

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Related Papers

American Journal of Physiology. Renal Physiology
Qingli ZhangThomas L Pallone
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Hai LinChunhua Cao
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Chunhua CaoThomas L Pallone
American Journal of Physiology. Renal Physiology
Chunhua CaoThomas L Pallone
© 2021 Meta ULC. All rights reserved