PMID: 9530932Apr 8, 1998Paper

Voltage gated Na+ channels contribute to membrane voltage fluctuation in alphaT3-1 pituitary gonadotroph cells

Neuroscience Letters
J K Tiwari, S K Sikdar

Abstract

AlphaT3-1 cells showed a slope resistance of 1.8 Gomega. The cell membrane surface was not smooth and a scanning electron micrograph showed a complex structure with blebs and microvilli like projections. The cells showed spontaneous fluctuations at zero current resting membrane potential and hyperpolarization increased the amplitude of membrane potential fluctuations. The amplitude of membrane potential fluctuations at hyperpolarized membrane potential was attenuated on application of TTX to the bath solution. The potential at which half steady state inactivation of isolated sodium current occurred, was at a very hyperpolarized potential (-95.4 mV). The study presented in this paper shows that the voltage gated sodium channels contribute to the increase in the amplitude of electrical noise with hyperpolarization in alphaT3-1 cells.

References

Jan 1, 1979·The Japanese Journal of Physiology·S Ozawa, S I Miyazaki
Mar 1, 1978·Acta Physiologica Scandinavica·S Ozawa, O Sand
Jul 8, 1999·European Biophysics Journal : EBJ·J K Tiwari, S K Sikdar

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Citations

Jul 24, 2010·Endocrine Reviews·Stanko S StojilkovicRichard Bertram
Aug 16, 2002·Transplant Immunology·U E NydeggerP Mohacsi
May 9, 2012·Journal of Neuroendocrinology·S S StojilkovicC A Stratakis
Jun 27, 2017·Frontiers in Endocrinology·Stanko S StojilkovicHana Zemkova

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