Voltage-gated sodium channels and pain pathways

Journal of Neurobiology
John N WoodM D Baker

Abstract

Acute, inflammatory, and neuropathic pain can all be attenuated or abolished by local treatment with sodium channel blockers such as lidocaine. The peripheral input that drives pain perception thus depends on the presence of functional voltage-gated sodium channels. Remarkably, two voltage-gated sodium channel genes (Nav1.8 and Nav1.9) are expressed selectively in damage-sensing peripheral neurons, while a third channel (Nav1.7) is found predominantly in sensory and sympathetic neurons. An embryonic channel (Nav1.3) is also upregulated in damaged peripheral nerves and associated with increased electrical excitability in neuropathic pain states. A combination of antisense and knock-out studies support a specialized role for these sodium channels in pain pathways, and pharmacological studies with conotoxins suggest that isotype-specific antagonists should be feasible. Taken together, these data suggest that isotype-specific sodium channel blockers could be useful analgesics.

References

Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y QuW A Catterall
Feb 1, 1994·Pflügers Archiv : European journal of physiology·W SchreibmayerI Lotan
Sep 26, 1996·Nature·L L Isom, W A Catterall
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·S Dib-HajjS G Waxman
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J J Toledo-AralG Mandel
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·S D Dib-HajjS G Waxman
Dec 1, 1998·Neuroscience Letters·S G KhasarJ D Levine
Jul 9, 1999·Journal of Neuroscience Research·J FjellJ A Black
Jan 8, 2000·The Journal of Biological Chemistry·K A Kazen-GillespieL L Isom
Feb 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·K MorganA P Jackson
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·B SampoB Dargent
Aug 11, 2000·Toxicon : Official Journal of the International Society on Toxinology·B M Olivera, L J Cruz
Oct 6, 2000·Science·T J BoucherS B McMahon
Feb 13, 2001·Trends in Pharmacological Sciences·M D Baker, J N Wood
Jul 4, 2001·Molecular Biotechnology·Y Le, B Sauer
Aug 10, 2001·Journal of Neurophysiology·M RenganathanS G Waxman
Jan 25, 2002·Nature·Hanno L TanJeffrey R Balser
Mar 9, 2002·Circulation Research·Isabelle DeschênesGordon F Tomaselli
Mar 20, 2002·Current Neurology and Neuroscience Reports·Frank Lehmann-HornReinhardt Rüdel
Apr 26, 2002·Trends in Neurosciences·Sulayman Dib-HajjStephen G Waxman

❮ Previous
Next ❯

Citations

Aug 26, 2009·Cellular and Molecular Life Sciences : CMLS·Reed B Jacob, Owen M McDougal
Nov 28, 2012·Experimental Brain Research·Jonas TesarzSiegfried Mense
Apr 18, 2008·The Journal of Membrane Biology·Ging Kuo WangSho-Ya Wang
Dec 30, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Renjie LiangXuehong Cao
Apr 23, 2008·Neurochemical Research·Jen-Kun Cheng, Ru-Rong Ji
Sep 10, 2008·Current Pain and Headache Reports·Rainer Maag, Ralf Baron
May 11, 2010·Journal of Feline Medicine and Surgery·Clare RusbridgeAngus Kennedy McFadyen
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Anindya BhattacharyaSandra R Chaplan
Sep 20, 2005·Nature Biotechnology·Shang-Zhong XuDavid J Beech
Aug 26, 2006·Nature Clinical Practice. Neurology·Ralf Baron
Feb 7, 2007·Nature Clinical Practice. Neurology·Anette T Møller, Troels S Jensen
Oct 24, 2006·Nature Medicine·Irmgard TegederClifford J Woolf
Jan 31, 2009·Nature Protocols·Katharina ZimmermannPeter W Reeh
May 11, 2011·The Journal of Biological Chemistry·Luis F Lopez-SantiagoLori L Isom
Apr 18, 2008·British Journal of Anaesthesia·R D'Mello, A H Dickenson
Jun 26, 2013·British Journal of Anaesthesia·A Ellis, D L H Bennett
Sep 11, 2012·Brain : a Journal of Neurology·Niels EijkelkampJohn N Wood
Jul 21, 2005·Regional Anesthesia and Pain Medicine·Masahiro TakahashiHitoshi Furuya
Apr 25, 2008·The Journal of Pharmacology and Experimental Therapeutics·Takafumi Horishita, R Adron Harris
May 4, 2011·Molecular Pharmacology·Sooyeon Jo, Bruce P Bean
Aug 3, 2005·The Journal of Clinical Investigation·Miriam H Meisler, Jennifer A Kearney
Nov 3, 2010·The Journal of Clinical Investigation·Ramin RaoufJohn N Wood
Jul 31, 2007·BMC Neuroscience·Michael A HenryS Rock Levinson
Jul 18, 2009·Reproductive Biology and Endocrinology : RB&E·Francisco M PintoLuz Candenas
Jan 10, 2012·Arthritis Research & Therapy·Niklas Schuelert, Jason J McDougall
Sep 23, 2008·Anesthesia and Analgesia·Chi-Fei WangGing Kuo Wang
Jul 6, 2013·Disease Models & Mechanisms·Vijayan Gangadharan, Rohini Kuner
Feb 21, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Michael H Ossipov, Frank Porreca
Sep 3, 2011·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Jayadave Shakher, Martin J Stevens
Jul 24, 2012·Marine Drugs·Magbubah EssackJohn A C Archer
Jun 1, 2007·Expert Opinion on Drug Discovery·Pierre Escoubas, Frank Bosmans
Feb 24, 2016·Frontiers in Microbiology·Bolong LiuShao-Jun Tang
Dec 4, 2015·The Veterinary Clinics of North America. Small Animal Practice·Catherine A Loughin
Apr 28, 2012·Molecular Pain·Noboru TakiguchiTerumasa Nakatsuka

❮ Previous
Next ❯

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