Voltage/pH-Driven Mechanized Silica Nanoparticles for the Multimodal Controlled Release of Drugs

ACS Applied Materials & Interfaces
Ting WangJiaJun Fu

Abstract

The major challenges of current drug delivery systems for combination chemotherapy focus on how to efficiently transport drugs to target sites and release multiple drugs in a programmed manner. Herein, we report a novel multidrug delivery system, MSNPs 1, based on mechanized silica nanoparticles, which were constructed through functionalization of mesoporous silica nanoparticles with the acid-cleavable intermediate linkages and the monoferrocene functionalized β-cyclodextrin (Fc-β-CD) as supramolecular nanovalves. MSNPs 1 achieved zero premature release in the physiological pH solution and realized two different release modalities. In modality 1, MSNPs 1 released the encapsulated drugs gemcitabine (GEM) and doxorubicin (DOX) in sequence when they were successively applied to voltage and acid stimuli. The release time and dosage of GEM were precisely controlled via external voltage. The subsequent acid-triggered release of DOX was attributed to breakage of the intermediate linkages containing ketal groups. Modality 2 is the concurrent release of these two drugs directly upon acid exposure. Furthermore, the cell viability experiments demonstrated that MSNPs 1 had an improved cytotoxicity to MCF7 cells in comparison with single DO...Continue Reading

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Citations

Dec 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chendi DingJiajun Fu
May 13, 2020·Chemical Society Reviews·Arturo Blanco-GómezMarcos D García
Mar 22, 2018·Signal Transduction and Targeted Therapy·Sudipta SenapatiPralay Maiti
Apr 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·ChenDi DingJiaJun Fu
Feb 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jianhua ZhuQunwei Xu
Aug 3, 2019·Journal of Functional Biomaterials·Carlos M WellsJ Amber Jennings
Dec 11, 2017·ACS Biomaterials Science & Engineering·Prabhu S YavvariAvinash Bajaj

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