Voltammetric and spectroscopic studies on binding of antitumor Morin, Morin-Cu complex and Morin-beta-cyclodextrin with DNA

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Y M TemerkMohamed Kotb

Abstract

A systematic comparative study of the binding of antitumor Morin and its complexes with DNA has been investigated in the Britton-Robison (BR) buffer solutions using voltammetric and spectroscopic methods. The results show that Morin molecule, acting as an intercalator, is inserted into the cavity of the beta-cyclodextrin (beta-CD) as well as into the base stacking domain of the DNA double helix. The interaction of Morin-Cu complex or the inclusion complex of Morin-beta-CD with ds-DNA causes hypochromism in the absorption spectra, along with pronounced changes in the electrochemical behavior of the Morin complexes. An isobestic point and a new spectrum band appeared indicating the formation of the new system of Morin-Cu-DNA at lambda(m)=391 nm and Morin-beta-CD-DNA at lambda(m)=375 nm. The intercalation of Morin-Cu and Morin-beta-CD complexes with DNA produces an electrochemically inactive supramolecular complex. The binding constants were calculated from the increase of the solubility, the strong hypochromism, and the decrease in peak current of Morin and its complexes upon the addition of the host molecules. Calculation of the thermodynamic parameters of the interaction of the inclusion complex of Morin-beta-CD with DNA, inclu...Continue Reading

References

Nov 15, 2000·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Y SongJ Gao

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Citations

Nov 4, 2010·DNA and Cell Biology·Gholamreza DehghanSoheila Kashanian
Jan 22, 2013·Analytical and Bioanalytical Chemistry·Yassin M TemerkWolfgang Schuhmann
Sep 25, 2009·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·G ArivazhaganT Thenappan
Oct 11, 2013·Luminescence : the Journal of Biological and Chemical Luminescence·Hongmei ZhangYanqing Wang
Jun 4, 2015·Journal of Photochemistry and Photobiology. B, Biology·Yassien TemerkMohamed Kotb
Oct 9, 2014·Nucleosides, Nucleotides & Nucleic Acids·Xiaoli XiongXingming Wang
Oct 30, 2016·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mariola Samsonowicz, Ewa Regulska

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