Voltammetric behaviour of rabeprazole at a glassy carbon electrode and its determination in tablet dosage form

Il Farmaco
A RadiT Wahdan

Abstract

The oxidative behaviour of rabeprazole was studied at a glassy carbon electrode in Britton-Robinson (BR) buffer solutions using cyclic, linear sweep and differential-pulse voltammetry. The oxidation process was shown to be irreversible over the pH range (6.0-11.0) and was diffusion-adsorption controlled. An analytical method was developed for the determination of rabeprazole in BR buffer solution at pH 8.0 as supporting electrolyte. The anodic peak current varied linearly with rabeprazole concentration in the range 1.0 x 10(-6) to 2.0 x 10(-5) M of rabeprazole with a limit of detection of 4.0 x 10(-7) M. Validation parameters, such as sensitivity, accuracy, precision and recovery, were evaluated. The proposed method was applied to the determination of rabeprazole in the tablet dosage form. The results were compared with those obtained by a published high-performance liquid chromatographic method. No difference was found statistically.

References

May 30, 2001·Journal of Pharmaceutical and Biomedical Analysis·G W SluggettZ Zhao
Mar 1, 2003·Journal of Pharmaceutical and Biomedical Analysis·Alaa El-GindyMoustafa M Maher

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Citations

Jul 1, 2008·Indian Journal of Pharmaceutical Sciences·A A Syed, Ayesha Syeda
Sep 28, 2010·Analytical Biochemistry·Vinod K GuptaShilpi Agarwal
Apr 14, 2016·Drug Development and Industrial Pharmacy·Yinhe TanChuanbin Wu
Jan 25, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·N V S RamakrishnaS Suresh Kumar
Mar 30, 2006·The Annals of Pharmacotherapy·Tracy D WatsonKimi S Vesta

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