Voltammetric detection of metal nanoparticles separated by liquid chromatography

Analytical Chemistry
Yang SongRoyce W Murray

Abstract

Fast-scan cyclic voltammetric (FSCV) detection of the separation of small (< 2-nm core diameter) organothiolate monolayer-protected gold clusters (MPCs) by high-performance liquid chromatography (HPLC) is demonstrated in this paper. Cyclic voltammograms taken at 1-s intervals (scan rate 150 V/s) display distinctive current-potential patterns for different MPCs, aiding in their identification. Previous amperometric detection of MPC separations required multiple HPLC runs at different electrode potentials to construct hydrodynamic current-potential voltammograms. Theory for ratiometric response of photodiode array absorbance and constant potential amperometry detectors was further tested on the fast-scan voltammetric detector and gave reasonable relative core size results for a mixture of Au140 and Au38 MPCs. In the first analysis of mixed MPC monolayer composition that is not simply an overall average result, preliminary HPLC experiments on MPCs with mixed hexanethiolate and ferrocenyl-octanethiolate monolayers resolved peaks that are shown to correspond to different average numbers of ferrocene-labeled ligands per MPC.

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Citations

Nov 7, 2008·Analytical and Bioanalytical Chemistry·Marinella FarréDamià Barceló
Feb 15, 2011·Analytical and Bioanalytical Chemistry·Petr S FedotovBoris Ya Spivakov
Aug 30, 2012·Nano Letters·Mamoru Tamura, Takuya Iida
Mar 14, 2013·Environmental Engineering Science·Susmita BandyopadhyayJorge L Gardea-Torresdey
May 23, 2015·Environmental Science and Pollution Research International·Véronique AdamGaetana Quaranta
Mar 25, 2017·ACS Applied Materials & Interfaces·Ali OthmanSilvana Andreescu
Jun 9, 2018·Electrophoresis·Tereza VaneckovaMarketa Vaculovicova
Jun 24, 2008·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Karen TiedeMartin Hassellov
Mar 25, 2020·Nanoscale·Yuichi NegishiTokuhisa Kawawaki
Apr 25, 2008·Analytical Chemistry·Andre HermansR Mark Wightman
Dec 20, 2018·Analytical Chemistry·Stefan Knoppe, Pascal Vogt
May 4, 2006·Journal of the American Chemical Society·Hironori TsunoyamaTatsuya Tsukuda
Jun 2, 2005·Journal of the American Chemical Society·Ramjee BalasubramanianRoyce W Murray

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