Volume and shape of subcortical grey matter structures related to headache: A cross-sectional population-based imaging study in the Nord-Trøndelag Health Study

Cephalalgia : an International Journal of Headache
Andreas K HusøyLars Jacob Stovner

Abstract

The relationship between subcortical nuclei and headache is unclear. Most previous studies were conducted in small clinical migraine samples. In the present population-based MRI study, we hypothesized that headache sufferers exhibit reduced volume and deformation of the nucleus accumbens compared to non-sufferers. In addition, volume and deformation of the amygdala, caudate, hippocampus, pallidum, putamen and thalamus were examined. In all, 1006 participants (50-66 years) from the third Nord-Trøndelag Health Survey, were randomly selected to undergo a brain MRI at 1.5 T. Volume and shape of the subcortical nuclei from T1 weighted 3D scans were obtained in FreeSurfer and FSL. The association with questionnaire-based headache categories (migraine and tension-type headache included) was evaluated using analysis of covariance. Individuals not suffering from headache were used as controls. Age, sex, intracranial volume and Hospital Anxiety and Depression Scale were used as covariates. No effect of headache status on accumbens volume and shape was present. Exploratory analyses showed significant but small differences in volume of caudate and putamen and in putamen shape between those with non-migrainous headache and the controls. A p...Continue Reading

References

Aug 1, 1987·AJR. American Journal of Roentgenology·F FazekasR A Zimmerman
Sep 22, 2000·Cephalalgia : an International Journal of Headache·K HagenG Bovim
Dec 1, 2009·The Journal of Headache and Pain·Knut HagenLars Jacob Stovner
Feb 2, 2010·NeuroImage·Shiva KeihaninejadUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 1, 2011·NeuroImage·Brian PatenaudeMark Jenkinson
Sep 23, 2011·Molecular Pain·Nasim MalekiDavid Borsook
Jul 5, 2012·Brain Structure & Function·Nasim MalekiDavid Borsook
Oct 17, 2012·Cold Spring Harbor Perspectives in Medicine·José L LanciegoJosé A Obeso
Mar 6, 2013·Arthritis and Rheumatism·Qi WuKaren D Davis
Mar 12, 2013·PM & R : the Journal of Injury, Function, and Rehabilitation·Neilly BuckalewDebra Weiner
May 15, 2013·The Journal of Pain : Official Journal of the American Pain Society·Kai YuanJie Tian
May 21, 2013·The Journal of Pain : Official Journal of the American Pain Society·Rachel F SmallwoodDonald A Robin
Dec 3, 2013·The Journal of Pain : Official Journal of the American Pain Society·Jixin LiuJie Tian
Dec 7, 2013·Journal of Neurology·Maria A RoccaMassimo Filippi
Jan 15, 2014·International Journal of Radiation Oncology, Biology, Physics·Pirus GhadjarAndrew Jackson
Jun 13, 2014·Human Reproduction Update·Jennifer BrawnKaty Vincent
Mar 15, 2015·European Journal of Pain : EJP·N A ElvemoA K Håberg
Apr 22, 2015·Cephalalgia : an International Journal of Headache·Lasse-Marius HonningsvågMattias Linde
Jul 16, 2015·The European Journal of Neuroscience·Elayne Vieira DiasCarlos Amilcar Parada
Oct 9, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stefano MagonTill Sprenger
Feb 3, 2016·Frontiers in Aging Neuroscience·Cui Ping MaoLei Zhang
Oct 27, 2016·Neuroscience·Vasiliki Mitsi, Venetia Zachariou
Oct 27, 2016·Neuroscience·Blaine Jacobs, Gregory Dussor

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Software Mentioned

FIRST
Statistical Parametric Mapping 8 ( SPM8 )
FMRIB
SPSS
Integrated Registration and Segmentation Tool ( FIRST )
FMRIB Library
FreeSurfer

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