Volume-controlled intermittent mandatory ventilation in preterm infants with hypoxemic episodes

Intensive Care Medicine
H HummlerAxel R Franz

Abstract

To test the hypothesis in ventilated very low birth weight infants with frequent hypoxemic episodes that volume-controlled synchronized intermittent mandatory ventilation (SIMV) vs. pressure-controlled SIMV reduces by at least 20% the time with hypoxemia (defined as SpO(2)<80%). Randomized cross-over design. University-based tertiary neonatal intensive care unit. 15 mechanically ventilated very low birth weight infants with frequent hypoxemic episodes. The infants were exposed in random order to volume-controlled and pressure-controlled SIMV for 4 h each. The target tidal volume during volume-controlled SIMV was matched to the tidal volume measured during pressure-controlled SIMV. FIO(2) was adjusted using uniform criteria to maintain SpO(2) within the target range (SpO(2) 80-92%). Primary outcome measure was the time with an SpO(2)<80%. Although tidal volume was maintained better during desaturations with volume-controlled SIMV, there was neither a significant difference in time with an SpO(2)<80% (expressed as proportion of total experimental time; median, interquartile range)-volume-control 10.6% (9.2-13.7%) vs. pressure-control 10.8% (8.3-13.3%)-nor in FIO(2) exposure. During volume-controlled SIMV the infants spent less ti...Continue Reading

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Citations

Mar 12, 2008·Current Opinion in Pediatrics·Nelson Claure, Eduardo Bancalari
Nov 28, 2013·Archives of Disease in Childhood. Fetal and Neonatal Edition·Wansheng PengEnMei Liu
Jul 16, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·C KlingenbergC J Morley
Jun 2, 2007·European Journal of Pediatrics·Anne Greenough, Atul Sharma
Oct 28, 2008·Seminars in Fetal & Neonatal Medicine·Helmut Hummler, Andreas Schulze
Oct 3, 2008·Seminars in Fetal & Neonatal Medicine·Nelson Claure, Eduardo Bancalari
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Sep 2, 2016·The Cochrane Database of Systematic Reviews·Anne GreenoughAnthony D Milner
Oct 19, 2017·The Cochrane Database of Systematic Reviews·Claus KlingenbergPeter G Davis

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