Volume exclusion in calcium selective channels

Biophysical Journal
Dezso BodaDirk Gillespie

Abstract

Another research group has proposed an interesting model for calcium channel selectivity. However, on the basis of their reported results we find it impossible to assess the merits of their model because their results and claims concerning selectivity are based on an extrapolation over four orders of magnitude to low Ca(2+) concentration. Their results and claims have been presented in several articles and reviews in several journals and, thus, need attention. In this article, we first establish that we obtain results on electrostatics and channel occupancies similar to the high-concentration simulations they present. We then perform grand canonical ensemble simulations that enable us to study micromolar Ca(2+) concentrations. We find that their model channel is only weakly Ca(2+) selective. A crucial problem with their model appears to be the placement of the negatively charged glutamate structural elements in fixed positions inside the protein rather than as flexible units inside the filter.

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Citations

Jan 8, 2010·European Biophysics Journal : EBJ·Ricky C K ChengBoris S Zhorov
May 12, 2010·European Biophysics Journal : EBJ·Daniel Krauss, Dirk Gillespie
Mar 8, 2011·European Biophysics Journal : EBJ·Daniel KraussDirk Gillespie
Apr 10, 2012·European Biophysics Journal : EBJ·David Jimenez-MoralesBob Eisenberg
Apr 29, 2009·The Journal of General Physiology·Dezso BodaWolfgang Nonner
Aug 10, 2013·The Journal of Chemical Physics·Dezső BodaDirk Gillespie
Mar 10, 2012·The Journal of Chemical Physics·Kenji KiyoharaKinji Asaka
Dec 17, 2014·The Journal of Chemical Physics·Jinn-Liang Liu, Bob Eisenberg
May 10, 2011·Journal of Computational Physics·Qiong ZhengGuo-Wei Wei
Oct 13, 2009·Biochimica Et Biophysica Acta·Attila MalasicsDezso Boda
Nov 25, 2014·Biophysical Journal·Dirk GillespieGerhard Meissner
May 15, 2013·Biophysical Journal·Bob Eisenberg
May 8, 2010·Physical Chemistry Chemical Physics : PCCP·Georg Schmeer, Alexander Maurer
Aug 8, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Jaydeep P BardhanDirk Gillespie
Mar 14, 2013·Physical Biology·I KaufmanR S Eisenberg
Sep 5, 2013·Physical Chemistry Chemical Physics : PCCP·J-F PietschmannZ Siwy
Jan 26, 2011·Physical Biology·Janhavi GiriBob Eisenberg
Oct 3, 2019·Physical Review. E·Zilong SongHuaxiong Huang
Jan 3, 2013·Physiology·Bob Eisenberg
Dec 18, 2013·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·I KaufmanR S Eisenberg
Jun 12, 2021·Physical Review Letters·W A T GibbyP V E McClintock
Jun 12, 2021·The Journal of Physical Chemistry. B·Kalyan ImmadisettyPeter M Kekenes-Huskey
Aug 15, 2012·The Journal of Physical Chemistry. B·Todor Dudev, Carmay Lim
Dec 8, 2010·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Bob Eisenberg
Jan 8, 2013·Journal of Chemical Theory and Computation·Justin J FinnertyPaolo Carloni
Aug 11, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Kenji KiyoharaKinji Asaka
Aug 21, 2012·The Journal of Physical Chemistry. B·Tzyy-Leng HorngBob Eisenberg
Sep 13, 2013·The Journal of Physical Chemistry. B·Jinn-Liang Liu, Bob Eisenberg
Sep 30, 2020·Mathematical Biosciences and Engineering : MBE·Peter W BatesMing Ji Zhang

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