PMID: 7520297Jun 1, 1994Paper

Volume loading with hypertonic saline solution: endocrinologic and circulatory responses

Journal of Cardiothoracic and Vascular Anesthesia
Joachim BoldtG Hempelmann

Abstract

Hypertonic saline solution appears to be an attractive method of volume expansion. In 45 patients undergoing elective aorto-coronary bypass grafting, endocrinologic and circulatory responses to volume loading with hypertonic saline solution prepared in low molecular weight (MW) hydroxyethyl starch (HES) solution (72 g/L NaCl, HES concentration: 6%; MW: 200,000 D; degree of substitution [DS]: 0.5) (HS-HES) was compared randomly to patients who had received low molecular weight HES solution (LMW-HES). A group of patients without volume loading served as a control. Volume was infused to double the low pulmonary capillary wedge pressure (PCWP < 5 mmHg) after induction of anesthesia. Plasma levels of atrial natriuretic peptide (ANP), endothelin, vasopressin, and catecholamines were measured before, during, and after cardiopulmonary bypass (CPB) until the first postoperative day. In addition to systemic circulatory changes, capillary skin blood flow was measured by laser Doppler flowmetry. ANP plasma concentration increased in both volume groups (HS-HES: +79%; HES: +32%), whereas it decreased in the control (-20%). Infusion of HS-HES resulted in an increase in plasma endothelin concentration before and after CPB (from 3 to 6 pg/mL). ...Continue Reading

References

Nov 1, 1991·British Journal of Anaesthesia·J BoldtG Hempelmann
Oct 15, 1985·Biochemical and Biophysical Research Communications·O Arjamaa, O Vuolteenaho
Jun 1, 1988·Journal of Cardiothoracic Anesthesia·P FlezzaniW D Watkins

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Citations

Feb 29, 2008·British Journal of Anaesthesia·J A Kolsen-PetersenE Tonnesen
Sep 1, 2007·Current Opinion in Critical Care·Sean M Bagshaw, Rinaldo Bellomo
Feb 21, 2002·Journal of Cardiothoracic and Vascular Anesthesia·Kati Järvelä, Seppo Kaukinen
May 15, 2012·The Journal of Thoracic and Cardiovascular Surgery·Roberta J NavickisMahlon M Wilkes
Oct 1, 1996·Journal of Computer-aided Molecular Design·D E ClarkC W Murray

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