Volume reduction of benign thyroid nodules 3 months after a single treatment with high-intensity focused ultrasound (HIFU)

Journal of Therapeutic Ultrasound
Huedayi KorkusuzFrank Grünwald

Abstract

High-intensity focused ultrasound (HIFU) is a promising, non-invasive technique in treating benign thyroid nodules (TNs). The aim of this study was to evaluate the efficacy of HIFU to induce clinically meaningful shrinkage in benign predominantly solid TNs and to identify variables that influence or predict the magnitude of TN volume reduction. For each of ten subjects, HIFU treatment was conducted on a single nodule. Nodular volume was measured sonographically at baseline and at 3 months post-procedure. Nodular function and early treatment assessment was done scintigraphically. Median nodular volume reduction was 0.7 ml absolute and 48.8% relative to pre-interventional size (p < 0.05). Absolute shrinkage was negatively correlated with the average treatment depth (τ = -0.61, p < 0.05). Absolute nodular volume was positively correlated with the scintigraphic nodular uptake reduction (τ = 0.66, p < 0.05). HIFU treatment of benign predominantly solid TNs appears to be safe and effective for inducing nodular shrinkage. Despite potential for improvement, a single treatment session with HIFU is already a viable alternative to more standard methods. The feasibility of multiple HIFU treatments requires further investigation. Due to the...Continue Reading

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Citations

Mar 23, 2017·Thyroid : Official Journal of the American Thyroid Association·Brian Hung-Hin LangKeith Wan-Hang Chiu
Apr 3, 2018·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·H KorkusuzF Grünwald
Dec 18, 2018·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Brian Hh LangKeith Wan-Hang Chiu
Jul 19, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Adrien Ben HamouHerve Monpeyssen
Mar 17, 2017·Journal of Ultrasound·Anna Pisani MaininiGiovanni Mauri
Aug 5, 2020·Expert Review of Medical Devices·Eleftherios SpartalisNikolaos Nikiteas
Apr 30, 2016·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Konstantin David KohlhaseFrank Grünwald
Apr 8, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Brian H H LangKeith Wan-Hang Chiu
May 20, 2017·Journal of Therapeutic Ultrasound·Brian Hung-Hin Lang, Arnold L H Wu
May 6, 2017·World Journal of Surgery·Yücel KorkusuzChristian Happel
Jun 4, 2021·Frontiers in Endocrinology·Alessandro BiscegliaRoberto Garberoglio
Jun 28, 2021·Drug Delivery and Translational Research·Samira Aghlara-FotovatOmid Veiseh

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Methods Mentioned

BETA
biopsy

Software Mentioned

EchoPulse®
R Core Team
R

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