Volume regulation and renal function at high altitude across gender

PloS One
Bernd HaditschNandu Goswami

Abstract

We investigated changes in volume regulating hormones and renal function at high altitudes and across gender. Included in this study were 28 subjects (n = 20 males; n = 8 females. ages: 19 - 65 yrs), who ascended to a height of 3440m (HA1), on the 3rd day and to 5050m (HA2), on the 14th day. Plasma and urinary creatinine and urinary osmolality as well as plasma levels of plasma renin activity (PRA), Aldosterone, antidiuretic hormone (ADH), and atrial natriuretic peptide (ANP) were measured. The plasma volume loss (PVL) was estimated from plasma density and hematocrit. Glomerular filtration rate (GFR) was measured based on nocturnal (9 hour) creatinine clearance; this was compared with various methods for estimation of GFR. The mean 24-hour urine production increased significantly in both sexes across the expedition. But PVL reached significance only in males. No changes in Na+ in plasma, urine or its fractional excretion were seen at both altitudes. Urinary osmolality decreased upon ascent to the higher altitudes. ADH and PRA decreased significantly at both altitudes in males but only at HA2 in females. However, no changes in aldosterone were seen across the sexes and at different altitudes. ANP increased significantly only in ...Continue Reading

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Citations

Jul 14, 2018·PloS One·Varun ChhabraMaramreddy Prasanna Kumar Reddy
Oct 26, 2018·Hypertension·Offdan Narvaez-GuerraJulio A Chirinos
Aug 9, 2020·Frontiers in Physiology·Lisa M PalubiskiJulie O'Neill
Oct 6, 2017·Frontiers in Physiology·Kiumars ShamlooSurya M Nauli
Oct 1, 2020·American Journal of Physiology. Renal Physiology·Andrew R SteeleCraig D Steinback
Dec 22, 2020·Nitric Oxide : Biology and Chemistry·Letizia RasicaMauro Marzorati
Oct 31, 2020·Journal of Clinical Medicine·Nandu GoswamiGerhard Cvirn
Mar 31, 2021·High Altitude Medicine & Biology·John P DelamereArthur R Bradwell
Apr 10, 2021·Journal of Physiology and Biochemistry·Ashish K SinghAnil K Pasupulati

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