PMID: 6980902Sep 1, 1982Paper

Volume regulation by human lymphocytes. Identification of differences between the two major lymphocyte subpopulations

The Journal of Clinical Investigation
R K CheungE W Gelfand

Abstract

Following exposure to hypotonic media, human peripheral blood lymphocytes swell initially but restore their isotonic volume within minutes. In contrast, tonsillar lymphocytes demonstrate a similar initial phase of swelling but fail to restore their isotonic volume. We have studied the ionic basis for this second or regulatory volume decrease (RVD) phase using lymphocytes from peripheral blood, tonsil, and thymus. RVD was characterized by 86Rb efflux and a decrease in K+ content. The increase in K+ permeability in response to hypotonic challenge was characteristic for T lymphocytes obtained from peripheral blood, tonsil, or thymus. B lymphocytes showed only a modest increase in K+ permeability and consequently little RVD. The data confirm that the response of peripheral blood and tonsillar lymphocytes to a hypotonic environment can be accounted for by differences in the proportions of T and B cells, and the differential behaviour of B and T lymphocytes is based on differences in membrane permeability to K+ upon swelling.

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Citations

Sep 1, 1992·Journal of Cellular Physiology·C BrodieE W Gelfand
Nov 1, 1995·Journal of Cellular Physiology·C BrodieE W Gelfand
Jan 1, 1985·Journal of Clinical Immunology·K G ChandyS Gupta
Jan 16, 2009·Bulletin of Experimental Biology and Medicine·R S KurbannazarovaR Z Sabirov
Jul 25, 1984·Biochimica Et Biophysica Acta·B SarkadiA Rothstein
Feb 11, 1999·Biochemical Pharmacology·C D Bortner, J A Cidlowski
Oct 11, 1984·The New England Journal of Medicine·E W GelfandS Grinstein
Jul 1, 1989·The Journal of Experimental Medicine·E W GelfandS Grinstein
Jan 1, 1990·The Journal of General Physiology·S Grinstein, J D Smith
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Carl D Bortner, John A Cidlowski
Jun 1, 1990·American Journal of Respiratory Cell and Molecular Biology·M A ChanE W Gelfand
Feb 1, 1988·The Journal of Clinical Investigation·S L MacDougallE W Gelfand
Jan 12, 2010·Journal of Biomedical Optics·Dmitry I StrokotovValeri P Maltsev
Jan 1, 1989·Annals of the New York Academy of Sciences·A Rothstein, C Bear
Sep 1, 1983·Journal of Cellular Physiology·S GrinsteinA Rothstein
Dec 1, 1984·Journal of Cellular Physiology·E W GelfandS Grinstein
Dec 1, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·S GrinsteinA Rothstein
Jul 1, 1983·The American Journal of Physiology·S GrinsteinE W Gelfand
Aug 14, 2019·Immunological Reviews·Trisha Mahtani, Bebhinn Treanor
Mar 1, 1984·The American Journal of Physiology·S GrinsteinE W Gelfand
Jun 12, 1986·Biochimica Et Biophysica Acta·E K Hoffmann
May 29, 1992·Biochemical and Biophysical Research Communications·A TordaiE W Gelfand

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