Volumetric capnography curves as lung function test to confirm bronchoconstriction after carbachol challenge in sedated dogs

Research in Veterinary Science
S ScheffzekYves Moens

Abstract

This study investigated volumetric capnography (VC) in detecting airway responsiveness following airway challenge using carbachol in seven sedated dogs via face mask. Nebulised saline was administered, followed by increasing concentrations of nebulised carbachol until airflow limitation occurred (EP). Dead space (DS) variables and shape indices of the VC curve were calculated automatically after entering arterial carbon dioxide tension. Airway DS, airway DS to tidal volume (VT) ratio and the intercept of slope 2 of the VC curve decreased significantly at EP by 10%, 13% and 16%, respectively, minute ventilation, VT and alveolar DS increased significantly at EP by 49%, 22% and 200%, respectively. We conclude that VC and derived indices may be used to verify a reaction to airway challenge caused by carbachol in sedated dogs.

References

Dec 13, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Anil AgarwalUttam Singh
Nov 1, 1950·The Journal of Clinical Investigation·W S FOWLER
Jun 15, 2004·Journal of Applied Physiology·Holger SchulzJoachim Heyder
Apr 2, 2005·Journal of Applied Physiology·G TusmanS H Böhm
Jul 6, 2005·The Veterinary Journal·Jesús TalaveraCécile Clercx
Oct 19, 2006·Intensive Care Medicine·Gerardo TusmanGöran Hedenstierna
Jun 26, 2007·Respirology : Official Journal of the Asian Pacific Society of Respirology·Andrea AlivertiPeter T Macklem
Apr 22, 2008·Critical Care : the Official Journal of the Critical Care Forum·Lisbet NiklasonBjörn Jonson
May 30, 2008·Clinical Physiology and Functional Imaging·J O SteissH Lindemann

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Citations

Feb 7, 2019·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Marcos Mello MoreiraIlma Aparecida Paschoal

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