Volumetric modulated arc therapy versus intensity-modulated proton therapy in the postoperative irradiation of thymoma

Journal of Cancer Research and Clinical Oncology
D FranceschiniMarta Scorsetti

Abstract

To investigate the role of intensity-modulated proton therapy (IMPT) compared to volumetric modulated arc therapy (VMAT) for the radiation treatment of thymoma cancer. Twenty patients were retrospectively planned for IMPT [with (IMPT_R1 or IMPT_R2 according to the approach adopted) and without robust optimization] and VMAT. The results were compared according to dose-volume metrics on the clinical and planning target volumes (CTV and PTV) and the main organs at risk (heart, breasts, lungs, spinal cord and oesophagus). Estimates of the excess absolute risk (EAR) of secondary cancer induction were determined for the oesophagus, the breasts and the composite lungs. For the heart, the relative risk (RR) of chronic heart failure (CHF) was assessed. IMPT and VMAT plans resulted equivalent in terms of target coverage for both the CTV and the PTV. The CTV homogeneity index resulted in 0.03 ± 0.01 and 0.04 ± 0.01 for VMAT and all IMPT plans, respectively. The conformality index resulted in 1.1 ± 0.1 and 1.2 ± 0.1 for VMAT and all IMPT plans. The mean dose to the breasts resulted in 10.5 ± 5.0, 4.5 ± 3.4, 4.7 ± 3.5 and 4.6 ± 3.4 Gy for VMAT, IMPT, IMPT_R1 and IMPT_R2. For the lungs, the mean dose was 9.6 ± 2.3, 3.5 ± 1.5, 3.6 ± 1.6 and 3...Continue Reading

References

Jan 1, 1991·The Annals of Thoracic Surgery·G MaggiE Ruffini
Jan 1, 1997·The Journal of Thoracic and Cardiovascular Surgery·E RuffiniG Maggi
Oct 21, 2003·International Journal of Cancer. Journal International Du Cancer·Lois B TravisWilliam D Travis
Dec 8, 2005·Acta Oncologica·Thomas Björk-ErikssonBengt Glimelius
Aug 29, 2007·Radiation Research·D L PrestonK Kodama
Apr 22, 2009·The Annals of Thoracic Surgery·Robert J KorstSanjay Mandal
Apr 28, 2010·International Journal of Radiation Oncology, Biology, Physics·Mary FengLori J Pierce
Oct 5, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Eric A Engels
Oct 5, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Daniel Gomez, Ritsuko Komaki
Nov 13, 2010·Thoracic Surgery Clinics·Nicolas Girard, Françoise Mornex
Jun 10, 2011·Radiation Oncology·Uwe SchneiderJürgen Besserer
Aug 24, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Frank DetterbeckMeinoshin Okumura
Aug 24, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Daniel GomezAndrea Bezjak
Feb 11, 2012·Medical Physics·Wei LiuRadhe Mohan
Mar 13, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sabine SieslingUNKNOWN RARECARE Working Group
Mar 15, 2013·The New England Journal of Medicine·Sarah C DarbyPer Hall
Jun 19, 2013·Expert Review of Anticancer Therapy·Alexandra GiannopoulouKonstantinos N Syrigos
Jan 24, 2014·Frontiers in Oncology·Ritsuko Komaki, Daniel R Gomez
Jun 24, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Z Song, Y Zhang
Dec 20, 2014·The Journal of Thoracic and Cardiovascular Surgery·Usman AhmadAndreas Rimner
Jun 28, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Tomoyuki HishidaUNKNOWN Japanese Association for Research on the Thymus (JART)
Sep 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N GirardUNKNOWN ESMO Guidelines Committee
Nov 18, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frederika A van NimwegenFlora E van Leeuwen
Feb 21, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jennifer VogelCharles B Simone
Mar 31, 2016·International Journal of Radiation Oncology, Biology, Physics·Yu Jin LimShilpen Patel
Jan 28, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Matthew W JacksonChad G Rusthoven
Sep 6, 2017·International Journal of Radiation Oncology, Biology, Physics·J VogelC B Simone
Nov 7, 2017·Ecancermedicalscience·Bleddyn Jones
Jun 8, 2018·Translational Lung Cancer Research·He J ZhuCatherine E Mercado
Aug 8, 2018·Future Oncology·Vivek KumarAbhinav Binod Chandra
Sep 13, 2018·Journal of Thoracic Disease·Jonas Willmann, Andreas Rimner
Jan 22, 2019·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Francesco FracchiollaMarco Schwarz
May 31, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Mario LevisUmberto Ricardi
Nov 19, 2019·The British Journal of Radiology·Aimee McNamaraHarald Paganetti

❮ Previous
Next ❯

Citations

May 8, 2021·World Journal of Clinical Oncology·Mikel RicoFelipe Couñago

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.