Volumetric modulated arc therapy (VMAT) in the combined modality treatment of anal cancer patients

The British Journal of Radiology
Pierfrancesco FrancoUmberto Ricardi

Abstract

To report clinical and dosimetric outcomes of a consecutive series of patients with anal cancer treated with volumetric-modulated arc therapy (VMAT) concomitant to chemotherapy (CT). A cohort of 39 patients underwent VMAT employing a schedule consisting of 50.4 Gy/28 fractions to the gross tumour volume (GTV) and 42 Gy/28 fractions to the elective nodal volumes for patients with cT2N0 disease. Patients with cT3-T4/N0-N3 tumours were prescribed 54 Gy/30 fractions to the GTV and 50.4 Gy/30 fractions to the gross nodal volumes if sized ≤3 cm or 54 Gy/30 fractions if > 3 cm. Elective nodal regions were given 45 Gy/30 fractions. CT was administered concurrently following Nigro's regimen. The primary end point was acute toxicity. Secondary end points were colostomy-free survival (CFS), disease-free survival (DFS), cancer-specific survival (CSS) and overall survival (OS). Dosimetric data are also provided. Median follow-up was 21 months. Maximum acute toxicities were: dermatologic-G3: 18%; gastrointestinal-G3: 5%; genitourinary-G3: 2%; anaemia-G2: 7%; leukopenia-G3: 28%; G4: 8%; neutropenia-G3: 13%; G4: 18%; thrombocytopenia-G3: 11%; and G4: 2%. The actuarial 2-year CFS was 77.9% [95% confidence interval (CI): 54-90.4%]. Actuarial 2-y...Continue Reading

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Citations

Apr 3, 2016·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P FrancoU Ricardi
Sep 1, 2017·Asia-Pacific Journal of Clinical Oncology·Francesca ArcadipaneUmberto Ricardi
Oct 5, 2018·Medical Oncology·Stefania MartiniPierfrancesco Franco
May 4, 2018·Radiation Oncology·Pierfrancesco FrancoAndrea Casadei Gardini
Mar 10, 2017·Expert Review of Anticancer Therapy·Pierfrancesco FrancoUmberto Ricardi
Sep 17, 2021·Journal of Cancer Research and Therapeutics·Avipsa DasIndranil Mallick

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