Volumetric MRI vs clinical predictors of Alzheimer disease in mild cognitive impairment

Neurology
A S FleisherLeon J Thal

Abstract

To compare volumetric MRI of whole brain and medial temporal lobe structures to clinical measures for predicting progression from amnestic mild cognitive impairment (MCI) to Alzheimer disease (AD). Baseline MRI scans from 129 subjects with amnestic MCI were obtained from participants in the Alzheimer's Disease Cooperative Study group's randomized, placebo-controlled clinical drug trial of donepezil, vitamin E, or placebo. Measures of whole brain, ventricular, hippocampal, and entorhinal cortex volumes were acquired. Participants were followed with clinical and cognitive evaluations until formal criteria for AD were met, or completion of 36 months of follow-up. Logistic regression modeling was done to assess the predictive value of all MRI measures, risk factors such as APOE genotype, age, family history of AD, education, sex, and cognitive test scores for progression to AD. Least angle regression modeling was used to determine which variables would produce an optimal predictive model, and whether adding MRI measures to a model with only clinical measures would improve predictive accuracy. Of the four MRI measures evaluated, only ventricular volumes and hippocampal volumes were predictive of progression to AD. Maximal predictive...Continue Reading

Citations

Jan 13, 2010·Archives of Neurology·Lei WangJames E Galvin
Jun 27, 2013·European Journal of Nuclear Medicine and Molecular Imaging·A BrückJ O Rinne
Jan 19, 2010·Annals of Nuclear Medicine·Alexander Drzezga
Oct 30, 2009·Psychological Medicine·B SchmandW A van Gool
May 26, 2010·Nature Reviews. Neurology·Blossom C M StephanCarole Dufouil
Dec 24, 2009·The Clinical Neuropsychologist·Greg J Lamberty
Aug 2, 2008·Brain : a Journal of Neurology·Sean M NestorUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 29, 2009·Alzheimer Disease and Associated Disorders·Sanja KovacevicUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 5, 2012·Alzheimer Disease and Associated Disorders·Kate E MacdonaldUNKNOWN ADNI investigators
May 23, 2013·Alzheimer Disease and Associated Disorders·Liana G ApostolovaPaul M Thompson
Nov 11, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Rieko SakamotoMasaru Mimura
Aug 21, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M FilippiUNKNOWN European Federation of the Neurologic Societies
Jan 31, 2013·Stroke; a Journal of Cerebral Circulation·Galit WeinsteinSudha Seshadri
May 4, 2010·BMC Medical Informatics and Decision Making·Nicolas M FuriakTimothy M Klein
Feb 11, 2016·Ageing Research Reviews·Lisette H J KikkertClaudine J Lamoth
Mar 26, 2013·Neuroscience and Biobehavioral Reviews·Heidi I L JacobsAlexander T Sack
Oct 11, 2015·Human Brain Mapping·Pierrick CoupéUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Sep 19, 2015·Neuroinformatics·Wai Yen LohDeanne K Thompson
Dec 7, 2011·Neurobiology of Aging·Clifford R Jack
Sep 22, 2011·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Estrella Gómez-TortosaM José Sainz
Jul 26, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Clifford R JackNorman L Foster
Feb 1, 2011·NeuroImage·Kewei ChenUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Sep 3, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Kaori ItoUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Sep 4, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Danielle C WhitehairUNKNOWN Alzheimer's Disease Cooperative Study
May 7, 2011·International Journal of Alzheimer's Disease·Meredith N BraskiePaul M Thompson
Jun 15, 2010·Neurobiology of Aging·Omid KohannimUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 24, 2010·Neurobiology of Aging·Rahul S DesikanUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 14, 2010·Neurobiology of Aging·Yi-Yu ChouUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 14, 2010·Neurobiology of Aging·Shannon L RisacherUNKNOWN Alzheimer's Disease Neuroimaging Initiative (ADNI)
Apr 13, 2010·Archives of Gerontology and Geriatrics·José L MolinuevoLorena Rami
Oct 3, 2008·Neurobiology of Aging·Gwénaëlle CathelineMichèle Allard
Nov 19, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Sarah J GreeneUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Feb 10, 2010·Human Brain Mapping·Liana G ApostolovaCharles S Decarli
Apr 24, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Hyon-Ah YiHugo Vrenken

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