Voluntary Control of Epileptiform Spike-Wave Discharges in Awake Rats

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Jeremy A TaylorDaniel S Barth

Abstract

Genetically inherited absence epilepsy in humans is typically characterized by brief (seconds) spontaneous seizures, which involve spike-wave discharges (SWDs) in the EEG and interruption of consciousness and ongoing behavior. Genetic (inbred) models of this disorder in rats have been used to examine mechanisms, comorbidities, and antiabsence drugs. SWDs have also been proposed as models of complex partial seizures (CPSs) following traumatic brain injury (post-traumatic epilepsy). However, the ictal characteristics of these rat models, including SWDs and associated immobility, are also prevalent in healthy outbred laboratory rats. We therefore hypothesized that SWDs are not always associated with classically defined absence seizures or CPSs. To test this hypothesis, we used operant conditioning in male rats to determine whether outbred strains, Sprague Dawley and Long-Evans, and/or the inbred WAG/Rij strain (a rat model of heritable human absence epilepsy) could exercise voluntary control over these epileptiform events. We discovered that both inbred and outbred rats could shorten the duration of SWDs to obtain a reward. These results indicate that SWD and associated immobility in rats may not reflect the obvious cognitive/beha...Continue Reading

Citations

Dec 9, 2017·Epilepsy Currents·Laura A Ewell
May 22, 2020·Brain : a Journal of Neurology·Vincenzo CrunelliFrançois David
May 1, 2020·Frontiers in Pharmacology·Gilles van Luijtelaar, Gerard van Oijen
Dec 18, 2019·Proceedings of the National Academy of Sciences of the United States of America·Evan WickerPatrick A Forcelli
Dec 21, 2019·Epilepsy & Behavior : E&B·Márcio Flávio Dutra MoraesVinicius Rosa Cota
Mar 18, 2020·Neurobiology of Disease·Denise K GrosenbaughHoward P Goodkin

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